Frontiers in Endocrinology (Jun 2023)
Endoplasmic reticulum homeostasis: a potential target for diabetic nephropathy
- Ming Yang,
- Ming Yang,
- Chongbin Liu,
- Chongbin Liu,
- Na Jiang,
- Na Jiang,
- Yan Liu,
- Yan Liu,
- Shilu Luo,
- Shilu Luo,
- Chenrui Li,
- Chenrui Li,
- Hao Zhao,
- Hao Zhao,
- Yachun Han,
- Yachun Han,
- Wei Chen,
- Wei Chen,
- Li Li,
- Li Li,
- Li Xiao,
- Li Xiao,
- Lin Sun,
- Lin Sun
Affiliations
- Ming Yang
- Department of Nephrology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China
- Ming Yang
- Hunan Key Laboratory of Kidney Disease and Blood Purification, Changsha, Hunan, China
- Chongbin Liu
- Department of Nephrology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China
- Chongbin Liu
- Hunan Key Laboratory of Kidney Disease and Blood Purification, Changsha, Hunan, China
- Na Jiang
- Department of Nephrology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China
- Na Jiang
- Hunan Key Laboratory of Kidney Disease and Blood Purification, Changsha, Hunan, China
- Yan Liu
- Department of Nephrology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China
- Yan Liu
- Hunan Key Laboratory of Kidney Disease and Blood Purification, Changsha, Hunan, China
- Shilu Luo
- Department of Nephrology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China
- Shilu Luo
- Hunan Key Laboratory of Kidney Disease and Blood Purification, Changsha, Hunan, China
- Chenrui Li
- Department of Nephrology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China
- Chenrui Li
- Hunan Key Laboratory of Kidney Disease and Blood Purification, Changsha, Hunan, China
- Hao Zhao
- Department of Nephrology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China
- Hao Zhao
- Hunan Key Laboratory of Kidney Disease and Blood Purification, Changsha, Hunan, China
- Yachun Han
- Department of Nephrology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China
- Yachun Han
- Hunan Key Laboratory of Kidney Disease and Blood Purification, Changsha, Hunan, China
- Wei Chen
- Department of Nephrology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China
- Wei Chen
- Hunan Key Laboratory of Kidney Disease and Blood Purification, Changsha, Hunan, China
- Li Li
- Department of Nephrology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China
- Li Li
- Hunan Key Laboratory of Kidney Disease and Blood Purification, Changsha, Hunan, China
- Li Xiao
- Department of Nephrology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China
- Li Xiao
- Hunan Key Laboratory of Kidney Disease and Blood Purification, Changsha, Hunan, China
- Lin Sun
- Department of Nephrology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China
- Lin Sun
- Hunan Key Laboratory of Kidney Disease and Blood Purification, Changsha, Hunan, China
- DOI
- https://doi.org/10.3389/fendo.2023.1182848
- Journal volume & issue
-
Vol. 14
Abstract
The endoplasmic reticulum (ER) is the most vigorous organelle in intracellular metabolism and is involved in physiological processes such as protein and lipid synthesis and calcium ion transport. Recently, the abnormal function of the ER has also been reported to be involved in the progression of kidney disease, especially in diabetic nephropathy (DN). Here, we reviewed the function of the ER and summarized the regulation of homeostasis through the UPR and ER-phagy. Then, we also reviewed the role of abnormal ER homeostasis in residential renal cells in DN. Finally, some ER stress activators and inhibitors were also summarized, and the possibility of maintaining ER homeostasis as a potential therapeutic target for DN was discussed.
Keywords
