The role of SARS-COV-2 infection in promoting abnormal immune response and sepsis: A comparison between SARS-COV-2-related sepsis and sepsis from other causes

Andrea Piccioni; Laura Franza; Federico Rosa; Marcello Candelli; Marcello Covino; Michela Ferrara; Gianpietro Volonnino; Giuseppe Bertozzi; Maria Vittoria Zamponi; Aniello Maiese; Gabriele Savioli; Francesco Franceschi; Raffaele La Russa

Infectious Medicine (Sep 2023)

The role of SARS-COV-2 infection in promoting abnormal immune response and sepsis: A comparison between SARS-COV-2-related sepsis and sepsis from other causes

Andrea Piccioni,
Laura Franza,
Federico Rosa,
Marcello Candelli,
Marcello Covino,
Michela Ferrara,
Gianpietro Volonnino,
Giuseppe Bertozzi,
Maria Vittoria Zamponi,
Aniello Maiese,
Gabriele Savioli,
Francesco Franceschi,
Raffaele La Russa

Affiliations

Andrea Piccioni: Department of Emergency Medicine, Fondazione Policlinico Universitario A. Gemelli IRCCS, 1-00168 Rome, Italy; Corresponding author.
Laura Franza: Università Cattolica del Sacro Cuore, 1-00168 Rome, Italy
Federico Rosa: Università Cattolica del Sacro Cuore, 1-00168 Rome, Italy
Marcello Candelli: Department of Emergency Medicine, Fondazione Policlinico Universitario A. Gemelli IRCCS, 1-00168 Rome, Italy
Marcello Covino: Department of Emergency Medicine, Fondazione Policlinico Universitario A. Gemelli IRCCS, 1-00168 Rome, Italy; Università Cattolica del Sacro Cuore, 1-00168 Rome, Italy
Michela Ferrara: Department of Anatomical, Histological, Forensic and Orthopedic Sciences, Sapienza University of Rome, 00186 Rome, Italy
Gianpietro Volonnino: Department of Anatomical, Histological, Forensic and Orthopedic Sciences, Sapienza University of Rome, 00186 Rome, Italy
Giuseppe Bertozzi: Department of Clinical and Experimental Medicine, Institute of Legal Medicine, University of Foggia, 71100 Foggia, Italy
Maria Vittoria Zamponi: Department of Anatomical, Histological, Forensic and Orthopedic Sciences, Sapienza University of Rome, 00186 Rome, Italy
Aniello Maiese: Department of Surgical, Medical, and Molecular Pathology and Critical Care Medicine, University of Pisa, via Roma 55, 56126 Pisa, Italy
Gabriele Savioli: Emergency Department, IRCCS Policlinico San Matteo, 27100 Pavia, Italy; Department of Clinical-Surgical, Diagnostic and Pediatric Sciences, University of Pavia, 27100 Pavia, Italy
Francesco Franceschi: Department of Emergency Medicine, Fondazione Policlinico Universitario A. Gemelli IRCCS, 1-00168 Rome, Italy; Università Cattolica del Sacro Cuore, 1-00168 Rome, Italy
Raffaele La Russa: Department of Clinical and Experimental Medicine, Institute of Legal Medicine, University of Foggia, 71100 Foggia, Italy

Journal volume & issue: Vol. 2, no. 3
pp. 202 – 211

Abstract

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Background: COVID-19 caused by SARS-CoV-2 virus is characterized by respiratory compromise and immune system involvement, even leading to serious disorders, such as cytokine storm. Methods: We then conducted a literature review on the topic of sepsis and covid-19, and in parallel conducted an experimental study on the histological finding of patients who died from SARS-Covid 19 infection and a control group. Results: Sepsis associated with covid-19 infection has some similarities and differences from that from other causes. Conclusion: In this paper the complex interplay between the 2 disorders was discussed, focusing on the similarities and on the effect that one could have on the other. A preliminary experimental section that demonstrates the multisystemic involvement in subjects who die from SARS-CoV-2 is also proposed.

Published in Infectious Medicine

ISSN: 2772-431X (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Infectious and parasitic diseases
Website: https://www.journals.elsevier.com/infectious-medicine

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