SAFETY AND EFFECTIVENESS OF INTRAARTICULAR ADMINISTRATION OF ADIPOSE-DERIVED STROMAL VASCULAR FRACTION FOR TREATMENT OF KNEE ARTICULAR CARTILAGE DEGENERATIVE DAMAGE: PRELIMINARY RESULTS OF A CLINICAL TRIAL

I. A. Smyshlyaev; S. I. Gilfanov; V. A. Kopylov; R. G. Gilmutdinov; I. I. Pulin; I. N. Korsakov; I. R. Gilmutdinova; A. P. Petrikina; P. S. Eremin; O. V. Kruchkova; V. P. Abeltsev; N. V. Zagorodniy; V. L. Zorin; V. S. Vasilyev; D. Yu. Pupynin; I. I. Eremin

doi:10.21823/2311-2905-2017-23-3-17-31

Travmatologiâ i Ortopediâ Rossii (Oct 2017)

SAFETY AND EFFECTIVENESS OF INTRAARTICULAR ADMINISTRATION OF ADIPOSE-DERIVED STROMAL VASCULAR FRACTION FOR TREATMENT OF KNEE ARTICULAR CARTILAGE DEGENERATIVE DAMAGE: PRELIMINARY RESULTS OF A CLINICAL TRIAL

I. A. Smyshlyaev,
S. I. Gilfanov,
V. A. Kopylov,
R. G. Gilmutdinov,
I. I. Pulin,
I. N. Korsakov,
I. R. Gilmutdinova,
A. P. Petrikina,
P. S. Eremin,
O. V. Kruchkova,
V. P. Abeltsev,
N. V. Zagorodniy,
V. L. Zorin,
V. S. Vasilyev,
D. Yu. Pupynin,
I. I. Eremin

Affiliations

I. A. Smyshlyaev: Central Clinical Hospital with Outpatient Health Center, Administrative Department of the President of the Russian Federation; Central State Medical Academy, Administrative Department of the President of the Russian Federation
S. I. Gilfanov: Central Clinical Hospital with Outpatient Health Center, Administrative Department of the President of the Russian Federation; Central State Medical Academy, Administrative Department of the President of the Russian Federation; Peoples’ Friendship University of Russia
V. A. Kopylov: Orenburg City Clinical Hospital N 4
R. G. Gilmutdinov: Orenburg Regional Clinical Donor Blood Center
I. I. Pulin: Central Clinical Hospital with Outpatient Health Center, Administrative Department of the President of the Russian Federation
I. N. Korsakov: Central Clinical Hospital with Outpatient Health Center, Administrative Department of the President of the Russian Federation
I. R. Gilmutdinova: Central Clinical Hospital with Outpatient Health Center, Administrative Department of the President of the Russian Federation
A. P. Petrikina: Central Clinical Hospital with Outpatient Health Center, Administrative Department of the President of the Russian Federation
P. S. Eremin: Central Clinical Hospital with Outpatient Health Center, Administrative Department of the President of the Russian Federation
O. V. Kruchkova: Central Clinical Hospital with Outpatient Health Center, Administrative Department of the President of the Russian Federation
V. P. Abeltsev: Joined Hospital with Outpatient Health Center, Administrative Department of the President of the Russian Federation
N. V. Zagorodniy: Peoples’ Friendship University of Russia
V. L. Zorin: Central Clinical Hospital with Outpatient Health Center, Administrative Department of the President of the Russian Federation
V. S. Vasilyev: South Ural State Medical University
D. Yu. Pupynin: Orenburg City Clinical Hospital N 4
I. I. Eremin: Central Clinical Hospital with Outpatient Health Center, Administrative Department of the President of the Russian Federation; Central State Medical Academy, Administrative Department of the President of the Russian Federation

DOI: https://doi.org/10.21823/2311-2905-2017-23-3-17-31
Journal volume & issue: Vol. 23, no. 3
pp. 17 – 31

Abstract

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The incidence of knee osteoarthritis tends to increase every year and constitutes more than 83% of overall OA morbidity. Moreover, the OA morbidity among younger patients is also increasing. However, currently available treatment methods do not provide quite satisfactory outcomes.Purpose of the study – to evaluate safety and efficacy of intraarticular introduction of autologous adipose-derived stromal vascular fraction for treatment of knee osteoarthritis.Material and methods. By the moment of writing the present report, 28 patients were included into the study. All patients underwent tumescent liposuction under local anesthesia. The stromal vascular fraction was isolated from lipoaspirate within 1,5 hours after harvesting and subsequently injected into the articular cavity. Follow-up period was 6 months after injections. The authors report on efficacy data of 10 patients who completed the study according to protocol and safety data of all 28 patients. Efficacy was evaluated basing on laboratory assessments and patient’s subjective assessment by validated questionnaires.Results. Neither adverse reactions no adverse events were observed. Significant decrease of pain severity by VAS was noted in one week after injection and pain score continued decreasing during the whole follow up period. The increase of KOOS score was noted starting on the fifth week after injection. KSS part 1 score increased in 8 weeks, KSS part 2 score — in 6 months after injection. Physical health, assessed with SF-36 questionnaire significantly improved in 2 and 6 months after the procedure. There was a clear trend towards improvement of mental health.Conclusion. Preliminary results of clinical study suggest intraarticular injection of autologous adipose-derived stromal vascular fraction to be a safe and efficient method of the treatment of knee osteoarthritis.

knee osteoarthritis, stromal vascular fraction, adipose-derived stem cells

Published in Travmatologiâ i Ortopediâ Rossii

ISSN: 2311-2905 (Print); 2542-0933 (Online)
Publisher: Vreden Russian Research Institute of Traumatology and Orthopedics
Country of publisher: Russian Federation
LCC subjects: Medicine: Surgery: Orthopedic surgery
Website: http://journal.rniito.org/

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