Sensors (Jun 2020)

Differential Sensing of Saccharides Based on an Array of Fluorinated Benzosiloxaborole Receptors

  • Paweł Ćwik,
  • Patrycja Ciosek-Skibińska,
  • Marcin Zabadaj,
  • Sergiusz Luliński,
  • Krzysztof Durka,
  • Wojciech Wróblewski

DOI
https://doi.org/10.3390/s20123540
Journal volume & issue
Vol. 20, no. 12
p. 3540

Abstract

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Fluorinated benzosiloxaboroles–silicon congeners of benzoxaboroles, were synthesized and tested as molecular receptors for mono- and disaccharides. The receptors differed in the Lewis acidity of the boron center as well as in the number of potential binding sites. The calculated stability constants indicated different binding affinity of benzosiloxaborole derivatives towards selected saccharides, enabling their classification using a receptor array-based sensing. Unique fluorescence fingerprints were created on the basis of competitive interactions of the studied receptors with both Alizarin Red S (ARS) and tested saccharide molecules. Detailed chemometric analysis of the obtained fluorescence data (based on partial least squares-discriminant analysis and hierarchical clustering analysis) provided the differential sensing of common saccharides, in particular the differentiation between glucose and fructose. In addition, DFT calculations were carried out to shed light on the binding mechanism under different pH conditions.

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