Nature Communications (Oct 2017)
High grade serous ovarian carcinomas originate in the fallopian tube
- S. Intidhar Labidi-Galy,
- Eniko Papp,
- Dorothy Hallberg,
- Noushin Niknafs,
- Vilmos Adleff,
- Michael Noe,
- Rohit Bhattacharya,
- Marian Novak,
- Siân Jones,
- Jillian Phallen,
- Carolyn A. Hruban,
- Michelle S. Hirsch,
- Douglas I. Lin,
- Lauren Schwartz,
- Cecile L. Maire,
- Jean-Christophe Tille,
- Michaela Bowden,
- Ayse Ayhan,
- Laura D. Wood,
- Robert B. Scharpf,
- Robert Kurman,
- Tian-Li Wang,
- Ie-Ming Shih,
- Rachel Karchin,
- Ronny Drapkin,
- Victor E. Velculescu
Affiliations
- S. Intidhar Labidi-Galy
- Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School
- Eniko Papp
- Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine
- Dorothy Hallberg
- Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine
- Noushin Niknafs
- Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine
- Vilmos Adleff
- Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine
- Michael Noe
- Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine
- Rohit Bhattacharya
- Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine
- Marian Novak
- Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School
- Siân Jones
- Personal Genome Diagnostics
- Jillian Phallen
- Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine
- Carolyn A. Hruban
- Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine
- Michelle S. Hirsch
- Department of Pathology, Brigham and Women’s hospital and Harvard Medical School
- Douglas I. Lin
- Department of Pathology, Brigham and Women’s hospital and Harvard Medical School
- Lauren Schwartz
- Department of Pathology, University of Pennsylvania Perelman School of Medicine
- Cecile L. Maire
- Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School
- Jean-Christophe Tille
- Division of Clinical Pathology, Faculty of Medicine, Geneva University Hospital
- Michaela Bowden
- Department of Pathology, Brigham and Women’s hospital and Harvard Medical School
- Ayse Ayhan
- Department of Pathology, Seirei Mikatahara Hospital
- Laura D. Wood
- Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine
- Robert B. Scharpf
- Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine
- Robert Kurman
- Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine
- Tian-Li Wang
- Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine
- Ie-Ming Shih
- Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine
- Rachel Karchin
- Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine
- Ronny Drapkin
- Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School
- Victor E. Velculescu
- Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine
- DOI
- https://doi.org/10.1038/s41467-017-00962-1
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 11
Abstract
It has previously been proposed that high-grade serous ovarian carcinoma (HGSOC) may originate from the fallopian tube. Here, the authors analyze genetic aberrances in fallopian tube lesions, ovarian cancers, and metastases from HGSOC patients and establish the evolutionary origins of HGSOC in the fallopian tube.
