Vitamin D Deficiency and Insufficiency in Patients with Cardiovascular Pathology

Abstract

Cardiovascular diseases (CVD) is an important problem of the national health service as well as worldwide. Consequently, many countries of the world appear to have vitamin D deficiency and insufficiency to be common, and data of the recent meta-analyses suggest vitamin D to be a new risk factor of CVD. We performed a clinical and diagnostic examination of 135 residents of the Western Belarus with arterial hypertension (39.3 %) and ischemic heart disease (IHD) (60.7 %), 34 males and 101 females aged 59.65 ± 8.16 years old and 28 practically healthy individuals. Results. By M.F. Holick classification vitamin D deficiency was determined in 78 % of the examined individuals, vitamin D insufficiency in 17 % and sufficiency in 4.5 % persons. There were no significant differences in frequency of 25(OH)D deficiency/insufficiency depending on the diagnosis. The blood plasma level of 25(OH)D lower than 17 nmol/l is associated with elevated systolic blood pressure. Inverse correlations were established between the 25(OH)D plasma level and body mass, body mass index, heart rate, diastolic blood pressure. In the IHD group there was a direct correlative relationship between the 25(OH)D plasma level and the index of endothelium dependent vasodilatation.

Keywords

• vitamin D
• arterial hypertension
• ischemic heart disease