Communications Biology (Jan 2022)
Analysis of the glyco-code in pancreatic ductal adenocarcinoma identifies glycan-mediated immune regulatory circuits
- Ernesto Rodriguez,
- Kelly Boelaars,
- Kari Brown,
- Katarina Madunić,
- Thomas van Ee,
- Frederike Dijk,
- Joanne Verheij,
- R. J. Eveline Li,
- Sjoerd T. T. Schetters,
- Laura L. Meijer,
- Tessa Y. S. Le Large,
- Else Driehuis,
- Hans Clevers,
- Sven C. M. Bruijns,
- Tom O’Toole,
- Sandra J. van Vliet,
- Maarten F. Bijlsma,
- Manfred Wuhrer,
- Geert Kazemier,
- Elisa Giovannetti,
- Juan J. Garcia-Vallejo,
- Yvette van Kooyk
Affiliations
- Ernesto Rodriguez
- Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Molecular Cell Biology and Immunology, Cancer Center Amsterdam, Amsterdam Infection and Immunity Institute
- Kelly Boelaars
- Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Molecular Cell Biology and Immunology, Cancer Center Amsterdam, Amsterdam Infection and Immunity Institute
- Kari Brown
- Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Molecular Cell Biology and Immunology, Cancer Center Amsterdam, Amsterdam Infection and Immunity Institute
- Katarina Madunić
- Center for Proteomics and Metabolomics, Leiden University Medical Center
- Thomas van Ee
- Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Molecular Cell Biology and Immunology, Cancer Center Amsterdam, Amsterdam Infection and Immunity Institute
- Frederike Dijk
- Amsterdam UMC, Academic Medical Center Amsterdam, University of Amsterdam, Department of Pathology, Cancer Center Amsterdam
- Joanne Verheij
- Amsterdam UMC, Academic Medical Center Amsterdam, University of Amsterdam, Department of Pathology, Cancer Center Amsterdam
- R. J. Eveline Li
- Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Molecular Cell Biology and Immunology, Cancer Center Amsterdam, Amsterdam Infection and Immunity Institute
- Sjoerd T. T. Schetters
- Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Molecular Cell Biology and Immunology, Cancer Center Amsterdam, Amsterdam Infection and Immunity Institute
- Laura L. Meijer
- Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Surgery, Cancer Center Amsterdam
- Tessa Y. S. Le Large
- Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Surgery, Cancer Center Amsterdam
- Else Driehuis
- Oncode Institute, Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences and UMC Utrecht
- Hans Clevers
- Oncode Institute, Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences and UMC Utrecht
- Sven C. M. Bruijns
- Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Molecular Cell Biology and Immunology, Cancer Center Amsterdam, Amsterdam Infection and Immunity Institute
- Tom O’Toole
- Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Molecular Cell Biology and Immunology, Cancer Center Amsterdam, Amsterdam Infection and Immunity Institute
- Sandra J. van Vliet
- Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Molecular Cell Biology and Immunology, Cancer Center Amsterdam, Amsterdam Infection and Immunity Institute
- Maarten F. Bijlsma
- Amsterdam UMC, University of Amsterdam, LEXOR, Center for Experimental and Molecular Medicine, Cancer Center Amsterdam
- Manfred Wuhrer
- Center for Proteomics and Metabolomics, Leiden University Medical Center
- Geert Kazemier
- Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Surgery, Cancer Center Amsterdam
- Elisa Giovannetti
- Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Medical Oncology, Cancer Center Amsterdam
- Juan J. Garcia-Vallejo
- Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Molecular Cell Biology and Immunology, Cancer Center Amsterdam, Amsterdam Infection and Immunity Institute
- Yvette van Kooyk
- Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Molecular Cell Biology and Immunology, Cancer Center Amsterdam, Amsterdam Infection and Immunity Institute
- DOI
- https://doi.org/10.1038/s42003-021-02934-0
- Journal volume & issue
-
Vol. 5,
no. 1
pp. 1 – 15
Abstract
Rodriguez et al. present a transcriptomic analysis of glycosylation associated gene profiles, including bulk patient sequencing, sc-RNA seq, cell lines and organoids, to examine glycosylation in PDAC. They find 2 specific glycan profiles correlating with progression, clinical outcome and EMT, and conclude that the glyco-code contributes to the tolerogenic microenvironment in PDAC.
