Nature Communications (Nov 2016)

Epigenetic engineering reveals a balance between histone modifications and transcription in kinetochore maintenance

  • Oscar Molina,
  • Giulia Vargiu,
  • Maria Alba Abad,
  • Alisa Zhiteneva,
  • A. Arockia Jeyaprakash,
  • Hiroshi Masumoto,
  • Natalay Kouprina,
  • Vladimir Larionov,
  • William C. Earnshaw

DOI
https://doi.org/10.1038/ncomms13334
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 16

Abstract

Read online

Centromeres are centrochromatin domains with CENP-A and H3 nucleosomes carrying transcription-associated modifications. Here the authors target synthetic modules to the centromeres to show that transcription plus histone modifications are required for CENP-A assembly and centrochromatin maintenance.