Fibroblasts – the cellular choreographers of wound healing

Samuel Knoedler; Samuel Knoedler; Samuel Knoedler; Samuel Knoedler; Sonja Broichhausen; Ruiji Guo; Ruiji Guo; Ruoxuan Dai; Leonard Knoedler; Martin Kauke-Navarro; Fortunay Diatta; Bohdan Pomahac; Hans-Guenther Machens; Dongsheng Jiang; Yuval Rinkevich

doi:10.3389/fimmu.2023.1233800

Frontiers in Immunology (Aug 2023)

Fibroblasts – the cellular choreographers of wound healing

Samuel Knoedler,
Samuel Knoedler,
Samuel Knoedler,
Samuel Knoedler,
Sonja Broichhausen,
Ruiji Guo,
Ruiji Guo,
Ruoxuan Dai,
Leonard Knoedler,
Martin Kauke-Navarro,
Fortunay Diatta,
Bohdan Pomahac,
Hans-Guenther Machens,
Dongsheng Jiang,
Yuval Rinkevich

Affiliations

Samuel Knoedler: Department of Plastic Surgery and Hand Surgery, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany
Samuel Knoedler: Division of Plastic Surgery, Department of Surgery, Yale School of Medicine, New Haven, CT, United States
Samuel Knoedler: Division of Plastic Surgery, Department of Surgery, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, United States
Samuel Knoedler: Institute of Regenerative Biology and Medicine, Helmholtz Zentrum München, Munich, Germany
Sonja Broichhausen: Department of Hand, Plastic and Reconstructive Surgery, Microsurgery, Burn Trauma Center, BG Trauma Center Ludwigshafen, University of Heidelberg, Ludwigshafen, Germany
Ruiji Guo: Department of Plastic Surgery and Hand Surgery, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany
Ruiji Guo: Institute of Regenerative Biology and Medicine, Helmholtz Zentrum München, Munich, Germany
Ruoxuan Dai: Institute of Regenerative Biology and Medicine, Helmholtz Zentrum München, Munich, Germany
Leonard Knoedler: Division of Plastic Surgery, Department of Surgery, Yale School of Medicine, New Haven, CT, United States
Martin Kauke-Navarro: Division of Plastic Surgery, Department of Surgery, Yale School of Medicine, New Haven, CT, United States
Fortunay Diatta: Division of Plastic Surgery, Department of Surgery, Yale School of Medicine, New Haven, CT, United States
Bohdan Pomahac: Division of Plastic Surgery, Department of Surgery, Yale School of Medicine, New Haven, CT, United States
Hans-Guenther Machens: Department of Plastic Surgery and Hand Surgery, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany
Dongsheng Jiang: Institute of Regenerative Biology and Medicine, Helmholtz Zentrum München, Munich, Germany
Yuval Rinkevich: Institute of Regenerative Biology and Medicine, Helmholtz Zentrum München, Munich, Germany

DOI: https://doi.org/10.3389/fimmu.2023.1233800
Journal volume & issue: Vol. 14

Abstract

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Injuries to our skin trigger a cascade of spatially- and temporally-synchronized healing processes. During such endogenous wound repair, the role of fibroblasts is multifaceted, ranging from the activation and recruitment of innate immune cells through the synthesis and deposition of scar tissue to the conveyor belt-like transport of fascial connective tissue into wounds. A comprehensive understanding of fibroblast diversity and versatility in the healing machinery may help to decipher wound pathologies whilst laying the foundation for novel treatment modalities. In this review, we portray the diversity of fibroblasts and delineate their unique wound healing functions. In addition, we discuss future directions through a clinical-translational lens.

Published in Frontiers in Immunology

ISSN: 1664-3224 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy
Website: http://journal.frontiersin.org/journal/immunology

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