Electron cryotomography of SARS-CoV-2 virions reveals cylinder-shaped particles with a double layer RNP assembly

Lesley J. Calder; Thomas Calcraft; Saira Hussain; Ruth Harvey; Peter B. Rosenthal

doi:10.1038/s42003-022-04183-1

Communications Biology (Nov 2022)

Electron cryotomography of SARS-CoV-2 virions reveals cylinder-shaped particles with a double layer RNP assembly

Lesley J. Calder,
Thomas Calcraft,
Saira Hussain,
Ruth Harvey,
Peter B. Rosenthal

Affiliations

Lesley J. Calder: Structural Biology of Cells and Viruses Laboratory, The Francis Crick Institute
Thomas Calcraft: Structural Biology of Cells and Viruses Laboratory, The Francis Crick Institute
Saira Hussain: Worldwide Influenza Centre, The Francis Crick Institute
Ruth Harvey: Worldwide Influenza Centre, The Francis Crick Institute
Peter B. Rosenthal: Structural Biology of Cells and Viruses Laboratory, The Francis Crick Institute

DOI: https://doi.org/10.1038/s42003-022-04183-1
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 6

Abstract

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Electron cryotomography expands our knowledge of SARS-CoV-2 virus architecture and reveals a distinct and uniform morphology for which interactions between RNP subunits within the nucleocapsid and between the nucleocapsid and the membrane are likely to be important

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

About the journal