An RNAi screen for genes that affect nuclear morphology in <i>Caenorhabditis elegans</i> reveals the involvement of unexpected processes

Richa Maheshwari; Mohammad M Rahman; Daphna Joseph-Strauss; Orna Cohen-Fix

doi:10.1093/g3journal/jkab264

G3: Genes, Genomes, Genetics (Sep 2021)

An RNAi screen for genes that affect nuclear morphology in <i>Caenorhabditis elegans</i> reveals the involvement of unexpected processes

Richa Maheshwari,
Mohammad M Rahman,
Daphna Joseph-Strauss,
Orna Cohen-Fix

Affiliations

Richa Maheshwari: The Laboratory of Biochemistry and Genetics, The National Institute of Diabetes and Digestive and Kidney Diseases, The National Institutes of Health, Bethesda, MD 20892, USA
Mohammad M Rahman: ORCiD; The Laboratory of Biochemistry and Genetics, The National Institute of Diabetes and Digestive and Kidney Diseases, The National Institutes of Health, Bethesda, MD 20892, USA
Daphna Joseph-Strauss: The Laboratory of Biochemistry and Genetics, The National Institute of Diabetes and Digestive and Kidney Diseases, The National Institutes of Health, Bethesda, MD 20892, USA
Orna Cohen-Fix: ORCiD; The Laboratory of Biochemistry and Genetics, The National Institute of Diabetes and Digestive and Kidney Diseases, The National Institutes of Health, Bethesda, MD 20892, USA

DOI: https://doi.org/10.1093/g3journal/jkab264
Journal volume & issue: Vol. 11, no. 11

Abstract

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AbstractAberration in nuclear morphology is one of the hallmarks of cellular transformation. However, the processes that, when mis-regulated, result aberrant nuclear morphology are poorly understood. In this study, we carried out a systematic, high-throughput RNAi screen for genes that affect nuclear morphology in Caenorhabditis elegans

Published in G3: Genes, Genomes, Genetics

ISSN: 2160-1836 (Online)
Publisher: Oxford University Press
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General): Genetics
Website: https://academic.oup.com/g3journal

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