Influencing factors for sarcopenia in type 2 diabetes patients

Abstract

Objective To explore the demographic and commonly-used laboratory indicators influencing the occurrence of sarcopenia in patients with type 2 diabetes mellitus (T2DM). Methods A cross-sectional trial was conducted on 69 T2DM patients admitted to our hospital from July 2021 to June 2022. They were divided into case group and control group according to whether they complicated with sarcopenia or not. Their demographic data and laboratory indicators commonly used clinically were collected and compared. The variables with statistically significant differences in the univariate analysis were further included in multivariate logistic regression analysis to explore the influencing factors of the occurrence of sarcopenia in the T2DM patients. Results Analysis of demographic and common laboratory indicators showed that in the T2DM patients, the older the age, the higher risk of sarcopenia was (OR=1.091, 95%CI: 1.02-1.168, P=0.011); the lower the body mass index (BMI) value, the higher the risk of sarcopenia was (OR=0.691, 95%CI: 0.538-0.889, P=0.004); the higher the systolic blood pressure (SBP), the higher the risk of sarcopenia was (OR=1.066, 95%CI: 1.014-1.121, P=0.012). White blood cell count, fasting glucose, glycosylated hemoglobin, alanine aminotransferase, aspartate aminotransferase, albumin, uric acid, low-density lipoprotein, high-density lipoprotein, serum calcium, and serum phosphorus had no predictive value for sarcopenia in T2DM patients. Conclusion In T2DM patients, the demographic factors older age, low BMI and high SBP are associated with occurrence of sarcopenia. But, there has been no evidence of commonly used clinical laboratory indicators having such predictive value.

Keywords

• sarcopenia
• type 2 diabetes mellitus
• glucose metabolism