The Frequency of Human Papillomaviruses and Epstein-Barr Virus in Colorectal Cancer Samples in Algeria

Dahmani Bouchra; Boublenza Lamia; Behar Dalale; belatbi kacem; Breik Ikram; Benfoula Amel; Chabni Nafissa; Hassaine Hafida

Research in Molecular Medicine (Mar 2022)

The Frequency of Human Papillomaviruses and Epstein-Barr Virus in Colorectal Cancer Samples in Algeria

Dahmani Bouchra,
Boublenza Lamia,
Behar Dalale,
belatbi kacem,
Breik Ikram,
Benfoula Amel,
Chabni Nafissa,
Hassaine Hafida

Affiliations

Dahmani Bouchra: Department of Natural Sciences of Life, Earth and Universe, Faculty of Biology, University of Abou Bekr Belkaid, Tlemcen, Algeria.
Boublenza Lamia: Department of Natural Sciences of Life, Earth and Universe, Faculty of Biology, University of Abou Bekr Belkaid, Tlemcen, Algeria.
Behar Dalale: Department of Natural Sciences of Life, Earth and Universe, Faculty of Biology, University of Abou Bekr Belkaid, Tlemcen, Algeria.
belatbi kacem
Breik Ikram: Department of Pathological Anatomy, Popular Hospital Establishment of Dr. Benzardjeb, Ain Tmouchent, Algeria.
Benfoula Amel: Department of Pathological Anatomy, Popular Hospital Establishment of Dr. Benzardjeb, Ain Tmouchent, Algeria.
Chabni Nafissa: Department of Epidemiology, Dr. Tidjani Damerdji University Hospital, Tlemcen, Algeria.
Hassaine Hafida: Department of Natural Sciences of Life, Earth and Universe, Faculty of Biology, University of Abou Bekr Belkaid, Tlemcen, Algeria.

Journal volume & issue: Vol. 10, no. 1
pp. 1 – 8

Abstract

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Background: Environmental factors may play a role in colon cancer. In this view, several studies investigated tumor samples for the presence of various viral DNA with conflicting results. The purpose of this study is to investigate the prevalence of Human papillomaviruses (HPVs) and Epstein-Barr virus (EBV) in patients with colorectal carcinomas. Materials and Methods: In this study, we collected 74 tumorous paraffin-embedded tissues (Mean±SD age: 66.3±14.98) from the Pathology Department of a hospital in AinTemouchent and laboratories of pathological anatomy in western Algeria. DNA from each tissue was extracted and the presence of HPV and EBV was investigated using PCR. Results: None of our samples were HPV or EBV positive, and we failed to find an obvious correlation between EBV and HPV infections and this type of cancer. Conclusion: The results suggested that EBV and HPV infection is not common in patients with colorectal cancer in our population. However, the findings merit more investigations on a large number of cases.

Published in Research in Molecular Medicine

ISSN: 2322-1348 (Print); 2322-133X (Online)
Publisher: Mazandaran University of Medical Sciences and Health Services
Country of publisher: Iran, Islamic Republic of
LCC subjects: Medicine: Medicine (General)
Website: http://rmm.mazums.ac.ir/

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