Infection and Drug Resistance (Aug 2024)
Association Between COVID-19 and Diabetes Management Indices in Japanese Type 2 Diabetes Mellitus Patients: A Single-Center, Retrospective Study
Abstract
Kazuhiro Furumachi,1 Tatsuki Kagatsume,2 Akari Higuchi,2 Mariko Kozaru,2 Etsuko Kumagai,1 Keiko Hosohata2 1Department of Nephrology, Kenwakai Hospital, Nagano, Japan; 2Education and Research Center for Clinical Pharmacy, Faculty of Pharmacy, Osaka Medical and Pharmaceutical University, Osaka, JapanCorrespondence: Keiko Hosohata, Education and Research Center for Clinical Pharmacy, Faculty of Pharmacy, Osaka Medical and Pharmaceutical University, Osaka, Japan, Tel +81-72-690-1271, Fax +81-72-690-1023, Email [email protected]: The aim of the study was to determine the association between coronavirus disease 2019 (COVID-19) infection and diabetes management indices in patients with type 2 diabetes mellitus.Patients and Methods: A single-center, retrospective, observational study of patients with type 2 diabetes mellitus at Kenwakai Hospital (Nagano, Japan) was conducted. Data of 95 patients (mean age, 72 ± 12 years; men, 67.4%) who visited between March 1, 2019 and February 28, 2022 were obtained from the hospital’s electronic information system. COVID-19 was diagnosed by a chemiluminescent enzyme immunoassay (CLEIA).Results: There was no association between COVID-19 infection and age, sex, hemodialysis treatment status, or the Charlson Comorbidity Index. After adjustment for possible confounding factors, the incidence of COVID-19 infection was significantly correlated with HbA1c ≥ 7.0% (odds ratio [OR], 5.51; 95% confidence interval [CI], 1.30– 23.26).Conclusion: The results suggest an association between high HbA1c levels and COVID-19 infection in patients with type 2 diabetes mellitus. Appropriate management of diabetes mellitus, focusing on HbA1c levels, may help prevent COVID-19 infection and severe disease after infection.Keywords: Type 2 diabetes mellitus, COVID-19, risk factors, HbA1c, Japanese
