New Tripeptide Derivatives Asterripeptides A–C from Vietnamese Mangrove-Derived Fungus <em>Aspergillus terreus</em> LM.5.2

Elena V. Girich; Anton B. Rasin; Roman S. Popov; Ekaterina A. Yurchenko; Ekaterina A. Chingizova; Phan Thi Hoai Trinh; Ngo Thi Duy Ngoc; Mikhail V. Pivkin; Olesya I. Zhuravleva; Anton N. Yurchenko

doi:10.3390/md20010077

Marine Drugs (Jan 2022)

New Tripeptide Derivatives Asterripeptides A–C from Vietnamese Mangrove-Derived Fungus <em>Aspergillus terreus</em> LM.5.2

Elena V. Girich,
Anton B. Rasin,
Roman S. Popov,
Ekaterina A. Yurchenko,
Ekaterina A. Chingizova,
Phan Thi Hoai Trinh,
Ngo Thi Duy Ngoc,
Mikhail V. Pivkin,
Olesya I. Zhuravleva,
Anton N. Yurchenko

Affiliations

Elena V. Girich: G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Prospect 100-Letiya Vladivostoka, 159, 690022 Vladivostok, Russia
Anton B. Rasin: G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Prospect 100-Letiya Vladivostoka, 159, 690022 Vladivostok, Russia
Roman S. Popov: G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Prospect 100-Letiya Vladivostoka, 159, 690022 Vladivostok, Russia
Ekaterina A. Yurchenko: G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Prospect 100-Letiya Vladivostoka, 159, 690022 Vladivostok, Russia
Ekaterina A. Chingizova: G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Prospect 100-Letiya Vladivostoka, 159, 690022 Vladivostok, Russia
Phan Thi Hoai Trinh: Department of Marine Biotechnology, Nhatrang Institute of Technology Research and Application, Vietnam Academy of Science and Technology, Nha Trang 650000, Vietnam
Ngo Thi Duy Ngoc: Department of Marine Biotechnology, Nhatrang Institute of Technology Research and Application, Vietnam Academy of Science and Technology, Nha Trang 650000, Vietnam
Mikhail V. Pivkin: G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Prospect 100-Letiya Vladivostoka, 159, 690022 Vladivostok, Russia
Olesya I. Zhuravleva: School of Natural Sciences, Far Eastern Federal University, 690922 Vladivostok, Russia
Anton N. Yurchenko: G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Prospect 100-Letiya Vladivostoka, 159, 690022 Vladivostok, Russia

DOI: https://doi.org/10.3390/md20010077
Journal volume & issue: Vol. 20, no. 1
p. 77

Abstract

Read online

Three new tripeptide derivatives asterripeptides A–C (1–3) were isolated from Vietnamese mangrove-derived fungus Aspergillus terreus LM.5.2. Structures of isolated compounds were determined by a combination of NMR and ESIMS techniques. The absolute configurations of all stereocenters were determined using the Murfey’s method. The isolated compounds 1–3 contain a rare fungi cinnamic acid residue. The cytotoxicity of isolated compounds against several cancer cell lines and inhibition ability of sortase A from Staphylococcus aureus of asterripeptides A–C were investigated.

Published in Marine Drugs

ISSN: 1660-3397 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Biology (General)
Website: http://www.mdpi.com/journal/marinedrugs

About the journal

Abstract

Keywords