Analysis on short-term change of macular function and the correlates after intravitreal conbercept for CRVO-ME

Abstract

Abstract Aim To study the short-term change of macular function and the correlates after intravitreal conbercept for CRVO-ME. Study design Prospective, clinical study. Methods Twenty Three patients(23 eyes) were recruited, who were non-ischemia central retinal vein occlusion diagnosed by FFA (fundus fluorescein angiography) and treated with intravitreal conbercept for macular edema, best – corrected visual acuity ( BCVA), central macular thickness(CMT), amplitude density of P1 wave and implicit time of P1,N1 wave from ring 1 and ring 2 of mf-ERG were measured before and 1 week、2 month after treatment. Results Compared to the baseline, BCVA、CMT、amplitude density of P1 wave and implicit time of P1,N1 wave from ring 1 and ring 2 were greatly improved at 1 W、2 M after treatment; better results were gained at 2 M compared to 1 W; Pearson correlation analysis shows no significantly correlation between the improvement of mf-ERG with the change of BCVA、CMT. Conclusion The BCVA、the structure and the function of macular were greatly improved after intravitreal conbercept for central retinal vein occlusion induced macular edema; however no significantly correlation between the improvement of the function of macular with the strcture of macular and BCVA.

Keywords

• Non-ischemia central retinal vein occlusion
• Macular edema
• Conbercept
• Optical coherence tomography
• Multifocal electroretinogram