Multidisciplinary and Tailored Treatment of Locally Advanced Breast Cancer in Progression during Neoadjuvant Chemotherapy: Case Report

Letizia Cuniolo; Marco Gipponi; Federica Murelli; Francesca Depaoli; Chiara Cornacchia; Simonetta Franchelli; Marianna Pesce; Elena Ronda; Stefano Picardi; Raquel Diaz; Francesca Poggio; Daniele Friedman; Franco De Cian; Piero Fregatti

doi:10.3390/curroncol31050217

Current Oncology (May 2024)

Multidisciplinary and Tailored Treatment of Locally Advanced Breast Cancer in Progression during Neoadjuvant Chemotherapy: Case Report

Letizia Cuniolo,
Marco Gipponi,
Federica Murelli,
Francesca Depaoli,
Chiara Cornacchia,
Simonetta Franchelli,
Marianna Pesce,
Elena Ronda,
Stefano Picardi,
Raquel Diaz,
Francesca Poggio,
Daniele Friedman,
Franco De Cian,
Piero Fregatti

Affiliations

Letizia Cuniolo: Department of Surgical Sciences and Integrated Diagnostic (DISC), School of Medicine, University of Genoa, 16132 Genoa, Italy
Marco Gipponi: Breast Surgery Unit, IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy
Federica Murelli: Department of Surgical Sciences and Integrated Diagnostic (DISC), School of Medicine, University of Genoa, 16132 Genoa, Italy
Francesca Depaoli: Breast Surgery Unit, IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy
Chiara Cornacchia: Breast Surgery Unit, IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy
Simonetta Franchelli: Breast Surgery Unit, IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy
Marianna Pesce: Breast Surgery Unit, IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy
Elena Ronda: Department of Surgical Sciences and Integrated Diagnostic (DISC), School of Medicine, University of Genoa, 16132 Genoa, Italy
Stefano Picardi: Department of Surgical Sciences and Integrated Diagnostic (DISC), School of Medicine, University of Genoa, 16132 Genoa, Italy
Raquel Diaz: Department of Surgical Sciences and Integrated Diagnostic (DISC), School of Medicine, University of Genoa, 16132 Genoa, Italy
Francesca Poggio: Department of Medical Oncology, U.O. Oncologia Medica 2, IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy
Daniele Friedman: Department of Surgical Sciences and Integrated Diagnostic (DISC), School of Medicine, University of Genoa, 16132 Genoa, Italy
Franco De Cian: Department of Surgical Sciences and Integrated Diagnostic (DISC), School of Medicine, University of Genoa, 16132 Genoa, Italy
Piero Fregatti: Department of Surgical Sciences and Integrated Diagnostic (DISC), School of Medicine, University of Genoa, 16132 Genoa, Italy

DOI: https://doi.org/10.3390/curroncol31050217
Journal volume & issue: Vol. 31, no. 5
pp. 2856 – 2866

Abstract

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Locally advanced breast cancer (LABC) is a complex disease that requires a multidisciplinary approach. Neoadjuvant chemotherapy (NAC) is usually performed in order to achieve loco-regional radical resection; although its importance in the multidisciplinary approach to LABC is well recognized, a small number of patients show Progressive Disease (PD). No standard salvage treatment (ST) has been defined and different strategies can be adopted, such as second-line systemic therapies, radiation therapy, and surgery. Herein, a case of LABC in PD during NAC is reported with a literature review, with the aim of highlighting the importance of a tailored multidisciplinary treatment for each patient.

Published in Current Oncology

ISSN: 1198-0052 (Print); 1718-7729 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://www.mdpi.com/journal/curroncol

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