B cell response after SARS-CoV-2 mRNA vaccination in people living with HIV

Jacopo Polvere; Massimiliano Fabbiani; Gabiria Pastore; Ilaria Rancan; Barbara Rossetti; Miriam Durante; Sara Zirpoli; Enrico Morelli; Elena Pettini; Simone Lucchesi; Fabio Fiorino; Mario Tumbarello; Annalisa Ciabattini; Francesca Montagnani; Donata Medaglini

doi:10.1038/s43856-023-00245-5

Communications Medicine (Jan 2023)

B cell response after SARS-CoV-2 mRNA vaccination in people living with HIV

Jacopo Polvere,
Massimiliano Fabbiani,
Gabiria Pastore,
Ilaria Rancan,
Barbara Rossetti,
Miriam Durante,
Sara Zirpoli,
Enrico Morelli,
Elena Pettini,
Simone Lucchesi,
Fabio Fiorino,
Mario Tumbarello,
Annalisa Ciabattini,
Francesca Montagnani,
Donata Medaglini

Affiliations

Jacopo Polvere: Laboratory of Molecular Microbiology and Biotechnology, Department of Medical Biotechnologies, University of Siena
Massimiliano Fabbiani: Department of Medical Sciences, Infectious and Tropical Diseases Unit, University Hospital of Siena
Gabiria Pastore: Laboratory of Molecular Microbiology and Biotechnology, Department of Medical Biotechnologies, University of Siena
Ilaria Rancan: Department of Medical Sciences, Infectious and Tropical Diseases Unit, University Hospital of Siena
Barbara Rossetti: Department of Medical Sciences, Infectious and Tropical Diseases Unit, University Hospital of Siena
Miriam Durante: Department of Medical Biotechnologies, University of Siena
Sara Zirpoli: Laboratory of Molecular Microbiology and Biotechnology, Department of Medical Biotechnologies, University of Siena
Enrico Morelli: Department of Medical Biotechnologies, University of Siena
Elena Pettini: Laboratory of Molecular Microbiology and Biotechnology, Department of Medical Biotechnologies, University of Siena
Simone Lucchesi: Laboratory of Molecular Microbiology and Biotechnology, Department of Medical Biotechnologies, University of Siena
Fabio Fiorino: Laboratory of Molecular Microbiology and Biotechnology, Department of Medical Biotechnologies, University of Siena
Mario Tumbarello: Department of Medical Sciences, Infectious and Tropical Diseases Unit, University Hospital of Siena
Annalisa Ciabattini: Laboratory of Molecular Microbiology and Biotechnology, Department of Medical Biotechnologies, University of Siena
Francesca Montagnani: Department of Medical Sciences, Infectious and Tropical Diseases Unit, University Hospital of Siena
Donata Medaglini: Laboratory of Molecular Microbiology and Biotechnology, Department of Medical Biotechnologies, University of Siena

DOI: https://doi.org/10.1038/s43856-023-00245-5
Journal volume & issue: Vol. 3, no. 1
pp. 1 – 10

Abstract

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Polvere et al. investigate B cell responses after SARS-CoV-2 vaccination in people living with HIV undergoing anti-retroviral therapy. Spike-specific humoral and B cell responses persist for at least six months although a reduced ACE2/RBD binding inhibition capacity and different memory B phenotypes are observed compared to healthy controls.

Published in Communications Medicine

ISSN: 2730-664X (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Medicine
Website: https://www.nature.com/commsmed/

About the journal