Two Cu(II)-based coordination polymers: Photocatalytic dye degradation and treatment activity combined with BDNF modified bone marrow mesenchymal stem cells on craniocerebral trauma via increasing complement C3 expression

Abstract

Two novel mixed-ligand Cu(II) coordination polymers (CPs) {[Cu2(edpc)2(ga)2]·2H2O}n (1) and {[Cu(edpc)(bpdc)]·0.25(H2O)}n (2) (H2ga = glutaric acid, edpc = 9-ethyl-2,6-di-pyridin-4-yl-9H-carbazole, H2bpdc = biphenyl-4,4′-dicarboxylic acid) have been solvothermally formed through a π-conjugated carbazole-containing pyridine ligand under the presence of auxiliary ligands (H2ga for the complex 1 and H2bpdc for complex 2). Due to its good water stability of complex 2, it was applied in the photocatalytic rhodamine B (RhB), methylene blue (MB) and methyl orange (MO) degradation in unclean water, and the possible pathway of photocatalytic degradation was researched. Whether the compounds could enhance the treatment activity of the BDNF modified bone marrow mesenchymal stem cells (BMSC) against craniocerebral trauma was then evaluated. The recognition of the craniocerebral trauma mice was assessed by Morris water maze (MWM). The viability of the nerve cells in the brain was evaluated by Cell Counting Kit-8 (CCK-8). Then the enzyme-linked immuno sorbent assay (ELISA) detection was performed to detect the release content of the brain-originated neurotrophic factor and nerve promoting factor β in peripheral regions of cerebral hemorrhage. Finally, the expression levels of the complement C3 receptor on the nerve cells in the brain was also determined.

Keywords

• Coordination polymers
• Dye degradation
• X-ray single-crystal diffraction
• BMSC