Dataset for the spore surface proteome and hydrophobin A/RodA proteoforms of A.flavus
Mohammed Razeeth Shait Mohammed,
Muthu Kumar Balamurgan,
Rabbind Singh Amrathlal,
Priyadharshini Kannan,
Jeya Maheshwari Jayapal,
Venkatesh Prajna Namperumalsamy,
Lalitha Prajna,
Kuppamuthu Dharmalingam
Affiliations
Mohammed Razeeth Shait Mohammed
Department of Proteomics, Aravind Medical Research Foundation, Dr. G. Venkataswamy Eye Research Institute, Aravind Eye Care System, Madurai, TamilNadu, India
Muthu Kumar Balamurgan
Department of Proteomics, Aravind Medical Research Foundation, Dr. G. Venkataswamy Eye Research Institute, Aravind Eye Care System, Madurai, TamilNadu, India
Rabbind Singh Amrathlal
Department of Microbiology, Aravind Medical Research Foundation, Dr. G. Venkataswamy Eye Research Institute, Aravind Eye Care System, Madurai, TamilNadu, India
Priyadharshini Kannan
Department of Proteomics, Aravind Medical Research Foundation, Dr. G. Venkataswamy Eye Research Institute, Aravind Eye Care System, Madurai, TamilNadu, India
Jeya Maheshwari Jayapal
Department of Proteomics, Aravind Medical Research Foundation, Dr. G. Venkataswamy Eye Research Institute, Aravind Eye Care System, Madurai, TamilNadu, India
Venkatesh Prajna Namperumalsamy
Cornea Clinic, Aravind Eye Hospital, Aravind Eye Care System, Madurai, TamilNadu, India
Lalitha Prajna
Department of Ocular Microbiology, Aravind Eye Hospital, Aravind Eye Care System, Madurai, TamilNadu, India
Kuppamuthu Dharmalingam
Department of Proteomics, Aravind Medical Research Foundation, Dr. G. Venkataswamy Eye Research Institute, Aravind Eye Care System, Madurai, TamilNadu, India; Corresponding author. Aravind Medical Research Foundation, Dr. G. Venkataswamy Eye Research Institute, Aravind Eye Care System, No:1 Anna Nagar, Madurai, 20, TamilNadu, India.
Fungal keratitis is a major sight-threatening corneal infection: and mycotic keratitis is more common in tropical parts of the world including India. Aspergillus flavus and Fusarium are the predominant causative agents of corneal infection. We extracted conidial surface proteins of A. flavus from saprophyte and clinical isolates and analyzed the proteins using high resolution mass spectrometry. The data revealed ecotype specific alteration in surface proteome since the proteome profile of the clinical isolates and saprophyte showed significant differences. Detailed examination of the mass spec data of RodA proteins extracted from polyacrylamide gels revealed the presence of two proteoforms of this protein. We also identified the mechanism of formation of these two isoforms. Detailed analysis of this data and the conclusions derived are described in the article, “Identification of the proteoforms of surface localized Rod A of A. flavus and determination of the mechanism of proteoform generation” [1].
