Nature Communications (Aug 2020)
Elucidating the fundamental fibrotic processes driving abdominal adhesion formation
- Deshka S. Foster,
- Clement D. Marshall,
- Gunsagar S. Gulati,
- Malini S. Chinta,
- Alan Nguyen,
- Ankit Salhotra,
- R. Ellen Jones,
- Austin Burcham,
- Tristan Lerbs,
- Lu Cui,
- Megan E. King,
- Ashley L. Titan,
- R. Chase Ransom,
- Anoop Manjunath,
- Michael S. Hu,
- Charles P. Blackshear,
- Shamik Mascharak,
- Alessandra L. Moore,
- Jeffrey A. Norton,
- Cindy J. Kin,
- Andrew A. Shelton,
- Michael Januszyk,
- Geoffrey C. Gurtner,
- Gerlinde Wernig,
- Michael T. Longaker
Affiliations
- Deshka S. Foster
- Hagey Laboratory for Pediatric Regenerative Medicine, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine
- Clement D. Marshall
- Hagey Laboratory for Pediatric Regenerative Medicine, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine
- Gunsagar S. Gulati
- Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine
- Malini S. Chinta
- Hagey Laboratory for Pediatric Regenerative Medicine, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine
- Alan Nguyen
- Hagey Laboratory for Pediatric Regenerative Medicine, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine
- Ankit Salhotra
- Hagey Laboratory for Pediatric Regenerative Medicine, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine
- R. Ellen Jones
- Hagey Laboratory for Pediatric Regenerative Medicine, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine
- Austin Burcham
- Hagey Laboratory for Pediatric Regenerative Medicine, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine
- Tristan Lerbs
- Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine
- Lu Cui
- Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine
- Megan E. King
- Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine
- Ashley L. Titan
- Hagey Laboratory for Pediatric Regenerative Medicine, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine
- R. Chase Ransom
- Hagey Laboratory for Pediatric Regenerative Medicine, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine
- Anoop Manjunath
- Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine
- Michael S. Hu
- Hagey Laboratory for Pediatric Regenerative Medicine, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine
- Charles P. Blackshear
- Hagey Laboratory for Pediatric Regenerative Medicine, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine
- Shamik Mascharak
- Hagey Laboratory for Pediatric Regenerative Medicine, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine
- Alessandra L. Moore
- Hagey Laboratory for Pediatric Regenerative Medicine, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine
- Jeffrey A. Norton
- Hagey Laboratory for Pediatric Regenerative Medicine, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine
- Cindy J. Kin
- Department of Surgery, Stanford University School of Medicine
- Andrew A. Shelton
- Department of Surgery, Stanford University School of Medicine
- Michael Januszyk
- Hagey Laboratory for Pediatric Regenerative Medicine, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine
- Geoffrey C. Gurtner
- Hagey Laboratory for Pediatric Regenerative Medicine, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine
- Gerlinde Wernig
- Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine
- Michael T. Longaker
- Hagey Laboratory for Pediatric Regenerative Medicine, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine
- DOI
- https://doi.org/10.1038/s41467-020-17883-1
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 18
Abstract
Abdominal adhesions are a common cause of bowel obstruction, but knowledge regarding adhesion biology and anti-adhesion therapies remains limited. Here the authors report a systematic analysis of mouse and human adhesion tissues demonstrating that visceral fibroblast JUN and associated PDGFRA expression promote adhesions, and JUN suppression can prevent adhesion formation.
