EFFECTIVENESS OF NEW SKIN TEST (DIASKINTEST) IN REVELATION OF INFECTED ADOLESCENTS WHO HAD A CONTACT WITH PATIENTS WITH TUBERCULOSIS

Abstract

Skin tuberculin Mantoux test is widely used for the revelation of latent tuberculosis infection (LTI). Low specificity of the test (high rate of false-positive reactions due to the cross-sensitizing to vaccine strain Mycobacterium bovis BCG) results in difficulties in its interpretation. New method of LTI and active tuberculosis diagnostics is Diaskintest; it contains proteins CFP 10 and ESAT 6 which are absent in genome of M. bovis BCG and in most non-tuberculosis mycobacteria. The article presents results of a study of diagnostical value of Diaskintest (0.2 mkg/0.1 ml) and Mantoux test (with 2 TU PPD-L) in adolescents who had contacted with patients with tuberculosis. 143 adolescents from 2 colleges were examined, Diaskintest was performed in all of them, Mantoux test — in 131 patients, X-ray imaging including computer tomography — in all patients. Diaskintest demonstrated high sensitivity and specificity in diagnostics of tuberculosis in adolescents who had a contact with infected persons. 77.9% had positive Mantoux test (102/131), 5.6% — positive Diaskintest (8/143). Diaskintest revealed 5 cases of tuberculosis and 3 cases of LTI.Key words: adolescents, tuberculosis, Mantoux test, Diaskintest, diagnostics.(Voprosy sovremennoi pediatrii — Current Pediatrics. 2011; 10 (3): 70–75)