O15 B cell, T cell, cytotoxic/NK cell, and mitochondrial gene dysregulation patterns separate neuropsychiatric systemic lupus erythematosus patients into two distinct subgroups with differential anticipated response to targeted therapies

• ,
• Lorenzo Beretta,
• Maria Orietta Borghi,
• Ioannis Parodis,
• Dionysis Nikolopoulos,
• Marta E Alarcón-Riquelme,
• Yvonne Enman,
• Guillermo Barturen,
• Daniel Toro-Domínguez,
• Elena Carnero-Montoro,
• Chandra Mohan,
• Ellen Iacobaeus,
• Julius Lindblom,
• Jessica Castillo

Affiliations

30Dept. of Clinical Immunology and Rheumatology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, India

Lorenzo Beretta

Scleroderma Unit, Referral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca` Granda Ospedale Maggiore Policlinico, Milan, Italy

Maria Orietta Borghi

Experimental Laboratory of Immunological and Rheumatologic Researches, Istituto Auxologico Italiano Istituto di Ricovero e Cura a Carattere Scientifico, Cusano Milanino, Italy

Ioannis Parodis

Division of Rheumatology, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden

Dionysis Nikolopoulos

1 Center of Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy of Athens, Athens, Greece

Marta E Alarcón-Riquelme

Medical Genomics, Center Pfizer/University of Granada/Andalusian Regional Government for Genomics and Oncological Research (GENYO), Granada, Spain

Yvonne Enman

Division of Rheumatology, Dept. of Medicine, Karolinska Institutet and Rheumatology, Karolinska University Hospital, Stockholm, Sweden

Guillermo Barturen

1Dept. of Medical Genomics, Center for Genomics and Oncological Research (GENYO), Granada, Spain

Daniel Toro-Domínguez

1Dept. of Medical Genomics, Center for Genomics and Oncological Research (GENYO), Granada, Spain

Elena Carnero-Montoro

1Dept. of Medical Genomics, Center for Genomics and Oncological Research (GENYO), Granada, Spain

Chandra Mohan

professor

Ellen Iacobaeus

3Neuroimmunology Unit, Department of Clinical Neuroscience, Karolinska Institute Solna, Center for Molecular Medicine, Stockholm, Sweden

Julius Lindblom

1Department of medicine Solna, Karolinska Institutet, Sweden

Jessica Castillo

5Dept. of Biomedical Engineering, University of Houston, Houston, TX, USA