Nature Communications (May 2018)

Rapid host strain improvement by in vivo rearrangement of a synthetic yeast chromosome

  • B. A. Blount,
  • G-O. F. Gowers,
  • J. C. H. Ho,
  • R. Ledesma-Amaro,
  • D. Jovicevic,
  • R. M. McKiernan,
  • Z. X. Xie,
  • B. Z. Li,
  • Y. J. Yuan,
  • T. Ellis

DOI
https://doi.org/10.1038/s41467-018-03143-w
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 10

Abstract

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The Sc2.0 project has built the Synthetic Chromosome Rearrangement and Modification by LoxP-mediated Evolution (SCRaMbLE) system into their synthetic chromosomes. Here the authors use SCRaMbLE to rapidly develop, diversify and screen strains for diverse production and growth characteristics.