陆军军医大学学报 (Oct 2022)
Protective effects of sterofundin on myocardial injury in septic rats
Abstract
Objective To investigate the protective effects of sterofundin on myocardial injury in septic rats. Methods A total of 280 SPF SD rats (half male and female, 12~14 weeks old, 200~220 g) were randomly divided into 4 groups: sham operation (Sham) group, sepsis (Sep) group, conventional treatment (Ct) group (with Ringer's lactate solution+dopamine+cefuroxime sodium), and malate ringer's solution (Mr) group (with sterofundin+dopamine+cefuroxime sodium). The rat model of sepsis was inflicted by cecal ligation and puncture (CLP). Subsequently, the effects of sterofundin treatment on the myocardial injury, cardiac output (CO), oxygen supply and consumption, liver and kidney perfusion, liver and kidney functions, survival time and survival rate of septic rats were observed. Results The cardiac output (CO), cardiac index (CI) and stroke index (SI) were significantly decreased in the Sep group, while the injuries were improved to some extent in the Ct group (P < 0.05). As compared with the Sep group, the improvement was more obvious in the Mr group, with CO, CI and SI values increased by 48.9%, 52.9% and 21.7% respectively, and the values were also greatly higher than those in the Ct group (P < 0.05). The mean arterial blood pressure was remarkably declined to about 70 mmHg in the Sep group, slightly improved to around 90 mmHg in the Ct group, and notably elevated in the Mr group by 43.2% when compared with the Sep group (P < 0.05). In addition, the liver and kidney functions were significantly ameliorated in the Mr group, along with decreased troponin T and lactate dehydrogenase, enhanced oxygen supply and consumption, alleviated myocardial interstitial edema and less myocardial fiber breakage, which greatly improved the survival rate of animals (P < 0.05). Conclusion Sterofundin obviously improves the heart function and thus plays a protective role in organ functions in septic rats.
Keywords
