Endothelial microparticles and vascular parameters in subjects with and without arterial hypertension and coronary artery disease
Roberto Sansone,
Maximilian Baaken,
Patrick Horn,
Dominik Schuler,
Ralf Westenfeld,
Nicolas Amabile,
Malte Kelm,
Christian Heiss
Affiliations
Roberto Sansone
Division of Cardiology, Pulmonology, and Vascular Medicine, Medical Faculty, University Duesseldorf, Duesseldorf, Germany
Maximilian Baaken
Division of Cardiology, Pulmonology, and Vascular Medicine, Medical Faculty, University Duesseldorf, Duesseldorf, Germany
Patrick Horn
Division of Cardiology, Pulmonology, and Vascular Medicine, Medical Faculty, University Duesseldorf, Duesseldorf, Germany
Dominik Schuler
Division of Cardiology, Pulmonology, and Vascular Medicine, Medical Faculty, University Duesseldorf, Duesseldorf, Germany
Ralf Westenfeld
Division of Cardiology, Pulmonology, and Vascular Medicine, Medical Faculty, University Duesseldorf, Duesseldorf, Germany
Nicolas Amabile
Institut Mutualiste Montsouris, Paris, France
Malte Kelm
Division of Cardiology, Pulmonology, and Vascular Medicine, Medical Faculty, University Duesseldorf, Duesseldorf, Germany; CARID-Cardiovascular Research Institute Duesseldorf, Medical Faculty, University Duesseldorf, Duesseldorf, Germany
Christian Heiss
Division of Cardiology, Pulmonology, and Vascular Medicine, Medical Faculty, University Duesseldorf, Duesseldorf, Germany; University of Surrey, Faculty of Health and Medical Sciences, Guildford, UK; Surrey and Sussex Healthcare NHS Trust, Redhill, UK; Corresponding author at: University of Surrey, Faculty of Health and Medical Science, Department of Clinical and Experimental Medicine, Guildford, UK.
Endothelial microparticles (EMPs) are markers of endothelial injury and activation. The role of EMPs in arterial hypertension is not well understood and EMPs are increased both in arterial hypertension and coronary artery disease (CAD). The data presented here show EMPs as defined by CD31+/41−, CD62e+, and CD144+ surface markers and vascular hemodynamic parameters including office and central blood pressure, heart rate, aortic augmentation index, pulse wave velocity, flow-mediated dilation, nitroglycerin-mediated dilation, brachial artery diameter, hyperemic wall shear stress, and laser Doppler perfusion of the cutaneous microcirculation of normotensives and hypertensives with and without CAD.
