Multiple solitary plasmacytoma is very rare disease, which occurs in multiple sites of soft tissue, bone or both without multiple myeloma. Almost 80–90% of extramedullary plasmacytomas develop in the head and neck area. Involvement of the mediastinum is extremely rare. A few cases of mediastinal plasmacytoma have been reported, and to the best of our knowledge, there is only one previous report of multiple plasmacytomas involving the posterior mediastinum. Herein, we describe an unusual case of multiple solitary plasmacytomas in a 67-year-old male involving the posterior mediastinum and sternum without evidence of bone marrow involvement.
