hnRNPH1 recruits PTBP2 and SRSF3 to modulate alternative splicing in germ cells

Shenglei Feng; Jinmei Li; Hui Wen; Kuan Liu; Yiqian Gui; Yujiao Wen; Xiaoli Wang; Shuiqiao Yuan

doi:10.1038/s41467-022-31364-7

Nature Communications (Jun 2022)

hnRNPH1 recruits PTBP2 and SRSF3 to modulate alternative splicing in germ cells

Shenglei Feng,
Jinmei Li,
Hui Wen,
Kuan Liu,
Yiqian Gui,
Yujiao Wen,
Xiaoli Wang,
Shuiqiao Yuan

Affiliations

Shenglei Feng: Institute Reproductive Health, Tongji Medical College, Huazhong University of Science and Technology
Jinmei Li: Institute Reproductive Health, Tongji Medical College, Huazhong University of Science and Technology
Hui Wen: Institute Reproductive Health, Tongji Medical College, Huazhong University of Science and Technology
Kuan Liu: Institute Reproductive Health, Tongji Medical College, Huazhong University of Science and Technology
Yiqian Gui: Institute Reproductive Health, Tongji Medical College, Huazhong University of Science and Technology
Yujiao Wen: Institute Reproductive Health, Tongji Medical College, Huazhong University of Science and Technology
Xiaoli Wang: Institute Reproductive Health, Tongji Medical College, Huazhong University of Science and Technology
Shuiqiao Yuan: Institute Reproductive Health, Tongji Medical College, Huazhong University of Science and Technology

DOI: https://doi.org/10.1038/s41467-022-31364-7
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 19

Abstract

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Coordinated regulation of alternative splicing is essential for germ cell development. Here, the authors report that hnRNPH1 interacts with alternative splicing factors PTBP2 and SRSF3 in the germline to regulate pre-mRNA alternative splicing.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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