Development of a New Reverse Genetics System for Ebola Virus

Tianyu Gan; Dihan Zhou; Yi Huang; Shuqi Xiao; Ziyue Ma; Xiaoyou Hu; Yimin Tong; Huimin Yan; Jin Zhong

doi:10.1128/mSphere.00235-21

mSphere (Jun 2021)

Development of a New Reverse Genetics System for Ebola Virus

Tianyu Gan,
Dihan Zhou,
Yi Huang,
Shuqi Xiao,
Ziyue Ma,
Xiaoyou Hu,
Yimin Tong,
Huimin Yan,
Jin Zhong

Affiliations

Tianyu Gan: Unit of Viral Hepatitis, CAS Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Shanghai, China
Dihan Zhou: The Joint Laboratory for Translational Precision Medicine, Guangzhou Women and Children’s Medical Center, Guangzhou, China, and Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China
Yi Huang: Wuhan National Biosafety Laboratory, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China
Shuqi Xiao: Wuhan National Biosafety Laboratory, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China
Ziyue Ma: Unit of Viral Hepatitis, CAS Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Shanghai, China
Xiaoyou Hu: Unit of Viral Hepatitis, CAS Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Shanghai, China
Yimin Tong: Unit of Viral Hepatitis, CAS Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Shanghai, China
Huimin Yan: ORCiD; Mucosal Immunity Research Group, State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China
Jin Zhong: ORCiD; Unit of Viral Hepatitis, CAS Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Shanghai, China

DOI: https://doi.org/10.1128/mSphere.00235-21
Journal volume & issue: Vol. 6, no. 3

Abstract

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Ebola virus is among the most dangerous viral pathogens, with a case fatality rate of up to 90%. Since 2013, the two largest and most complex Ebola outbreaks in West Africa have revealed the lack of investigation on this notorious virus.

Published in mSphere

ISSN: 2379-5042 (Online)
Publisher: American Society for Microbiology
Country of publisher: United States
LCC subjects: Science: Microbiology
Website: https://journals.asm.org/journal/msphere

About the journal