ENDOTHELIAL DYSFUNCTION UNDER INFLUENCE OF IONIZING RADIATION: PATHOGENETIC BASIS AND OPPORTUNITIES OF PHARMACOLOGICAL CORRECTION

Abstract

The problem of radiation-induced lesions is becoming increasingly urgent. Studies in recent years show that one of the most vulnerable tissues is the endothelium when exposed to high doses of ionizing radiation. The study of the pathogenetic bases of this phenomenon has shown that damage to endotheliocytes occurs both at the expense of the direct exposure to radiation and due to the systemic disturbance of homeostasis which leads to the disadaptation of the executive and regulatory systems of the organism. In this review we considered the mechanisms of the development of endothelial dysfunction under the influence of radioactive radiation and possible methods of pharmacological correction of this condition.

Keywords

• endothelial dysfunction
• radiation
• radioprotectors
• endothelioprotectors