ZHAW Zurich University of Applied Sciences, Institute of Chemistry and Biological Chemistry (ICBC), Campus Reidbach, Einsiedlerstrasse 31, CH-8820 Wädenswil
Roger Marti
Ecole d'Ingénieurs et d'Architectes de Fribourg, Département des Technologies Industrielles, Filière de Chimie, Bd de Pérolles 80, CH-1705 Fribourg
Rainer Riedl
ZHAW Zurich University of Applied Sciences, Institute of Chemistry and Biological Chemistry (ICBC), Campus Reidbach, Einsiedlerstrasse 31, CH-8820 Wädenswil
Marina Simeunovic
Part of MS's Bachelor thesis; Empa Dübendorf, Überlandstrasse 129, CH-8600 Dübendorf
The Fmoc protection group is among the most commonly used protection groups for the amino function. A fast method for the thermal deavage of this protection group under base-free conditions without the need for dibenzofulvene scavengers is presented. The advantages of this method include straightforward testability by means of a simple high-temperature NMR experiment, usually high yields, and good selectivity towards the BOC protection group and t-butyl ethers.
