Chorionic Villus Sampling: Results of 135 High Risk Cases

Abstract

OBJECTIVE: To assess the data related to the first-trimester chorionic villus sampling performed in a single tertiary center. STUDY DESIGN: Transabdominal CVS perf ormed on 135 pregnant women, aged 18 to 38 y ears, at 11 to 14 weeks’ gestation, who sought prenatal diagnosis for v arious reasons, during the years 2000-2004. Procedure related f etal loss rate, the indications, results of cytogenetic analy sis and the clinical outcomes of patients was obtained retrospectiv ely. RESULTS: The indications f or prenatal diagnosis were enzymatic/DNA analysis f or single gene def ects (31.1%), adv anced positive screening test result (22.2%), advanced maternal age (17.8%), and maternal anxiety (11.9%). Kary oty ping was totally successful and chromosomal abnormality was detected in 3 women (2.2%). The procedure related f etal loss rate was 0.0%. CONCLUSION: CVS perf ormed 11-14 weeks of gestation by experienced operators is a quick, reliable, and saf e diagnostic method for prenatal diagnosis and the ov erall incidence of antenatal and neonatal complications is no greater than that expected f or a general population.

Keywords

• P renatal diagnosis, Chorionic villus sampling, Transabdominal, First-trimester, Outcome