The lysophospholipase D enzyme Gdpd3 is required to maintain chronic myelogenous leukaemia stem cells

Kazuhito Naka; Ryosuke Ochiai; Eriko Matsubara; Chie Kondo; Kyung-Min Yang; Takayuki Hoshii; Masatake Araki; Kimi Araki; Yusuke Sotomaru; Ko Sasaki; Kinuko Mitani; Dong-Wook Kim; Akira Ooshima; Seong-Jin Kim

doi:10.1038/s41467-020-18491-9

Nature Communications (Sep 2020)

The lysophospholipase D enzyme Gdpd3 is required to maintain chronic myelogenous leukaemia stem cells

Kazuhito Naka,
Ryosuke Ochiai,
Eriko Matsubara,
Chie Kondo,
Kyung-Min Yang,
Takayuki Hoshii,
Masatake Araki,
Kimi Araki,
Yusuke Sotomaru,
Ko Sasaki,
Kinuko Mitani,
Dong-Wook Kim,
Akira Ooshima,
Seong-Jin Kim

Affiliations

Kazuhito Naka: Department of Stem Cell Biology, Research Institute for Radiation Biology and Medicine, Hiroshima University
Ryosuke Ochiai: Pharmaceuticals and Life Sciences Division, Shimadzu Techno-Research
Eriko Matsubara: Pharmaceuticals and Life Sciences Division, Shimadzu Techno-Research
Chie Kondo: Pharmaceuticals and Life Sciences Division, Shimadzu Techno-Research
Kyung-Min Yang: Precision Medicine Research Center, Advanced Institute of Convergence Technology, Seoul National University
Takayuki Hoshii: Department of Molecular Oncology, Graduate School of Medicine, Chiba University
Masatake Araki: Institute of Resource Development and Analysis, Kumamoto University
Kimi Araki: Institute of Resource Development and Analysis, Kumamoto University
Yusuke Sotomaru: Natural Science Center for Basic Research and Development, Hiroshima University
Ko Sasaki: Department of Hematology and Oncology, Dokkyo Medical University School of Medicine
Kinuko Mitani: Department of Hematology and Oncology, Dokkyo Medical University School of Medicine
Dong-Wook Kim: Catholic Hematology Hospital, Leukemia Research Institute, The Catholic University of Korea
Akira Ooshima: Precision Medicine Research Center, Advanced Institute of Convergence Technology, Seoul National University
Seong-Jin Kim: Precision Medicine Research Center, Advanced Institute of Convergence Technology, Seoul National University

DOI: https://doi.org/10.1038/s41467-020-18491-9
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 15

Abstract

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How lipid metabolism can affect cancer recurrence is still unclear. Here, the authors show that the lysophospholipase D Gdpd3 maintains self-renewal capacity of CML stem cells by regulating the quiescence, and AKT/mTORC1 and Foxo3a/β-catenin signalling in an oncogene-independent manner.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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