Accurate real-time sensing tip for aqueous NO with optical fibers embedded in active hydrogel waveguide

Chieh-Wen Chung; May-Jywan Tsai; Peng-Wei Lin; Ding-Wen Huang; Kuan-Hsun Wang; Yu-An Chen; Hsin-Fei Meng; Hsiao-Wen Zan; Henrich Cheng; Limin Tong; Lei Zhang; Sheng-Fu Horng; Cheng-Hsiung Hung

doi:10.1063/1.4994231

AIP Advances (Feb 2018)

Accurate real-time sensing tip for aqueous NO with optical fibers embedded in active hydrogel waveguide

Chieh-Wen Chung,
May-Jywan Tsai,
Peng-Wei Lin,
Ding-Wen Huang,
Kuan-Hsun Wang,
Yu-An Chen,
Hsin-Fei Meng,
Hsiao-Wen Zan,
Henrich Cheng,
Limin Tong,
Lei Zhang,
Sheng-Fu Horng,
Cheng-Hsiung Hung

Affiliations

Chieh-Wen Chung: Department of Photonics and the Institute of Electro-Optical Engineering, National Chiao Tung University, Hsinchu 300, Taiwan, Republic of China
May-Jywan Tsai: Department of Neurosurgery, Taipei Veterans General Hospital, Taipei 112, Taiwan, Republic of China
Peng-Wei Lin: Department of Photonics and the Institute of Electro-Optical Engineering, National Chiao Tung University, Hsinchu 300, Taiwan, Republic of China
Ding-Wen Huang: Institute of Biomedical Engineering, National Chiao Tung University, Hsinchu 300, Taiwan, Republic of China
Kuan-Hsun Wang: Department of Photonics and the Institute of Electro-Optical Engineering, National Chiao Tung University, Hsinchu 300, Taiwan, Republic of China
Yu-An Chen: Institute of Physics, National Chiao Tung University, Hsinchu 300, Taiwan, Republic of China
Hsin-Fei Meng: Institute of Physics, National Chiao Tung University, Hsinchu 300, Taiwan, Republic of China
Hsiao-Wen Zan: Department of Photonics and the Institute of Electro-Optical Engineering, National Chiao Tung University, Hsinchu 300, Taiwan, Republic of China
Henrich Cheng: Department of Neurosurgery, Taipei Veterans General Hospital, Taipei 112, Taiwan, Republic of China
Limin Tong: State Key Laboratory of Modern Optical Instrumentation, College of Optical Science and Engineering, Zhejiang University, Hangzhou 310027, China
Lei Zhang: State Key Laboratory of Modern Optical Instrumentation, College of Optical Science and Engineering, Zhejiang University, Hangzhou 310027, China
Sheng-Fu Horng: Institute of Electronic Engineering, National Tsing Hua University, Hsinchu 300, Taiwan, Republic of China
Cheng-Hsiung Hung: Institute of Chemistry, Academia Sinica, Taipei 115, Taiwan, Republic of China

DOI: https://doi.org/10.1063/1.4994231
Journal volume & issue: Vol. 8, no. 2
pp. 025207 – 025207-14

Abstract

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A NO sensing tip is made by inserting two parallel optical fibers inside a poly 2-hydroxyethyl methacrylate (PolyHEMA) hydrogel waveguide mixed with the probe molecule 1, 2-Diaminoanthraquinone (DAQ). There is a length difference of 1 mm between the two fibers, and the light has to propagate through the difference from the short fiber to the long fiber. The total cross section area of the active hydrogel waveguide embedded with the fibers is only 3mm x 1.2 mm. For practical use the tip is housed in a needle for mechanical protection and the sensing tip is able to detect aqueous NO concentration around 1 μM with time resolution about 5 minutes. Such a sensing tip can be used to monitor the medical conditions inside the brain after a stroke or a brain injury.

Published in AIP Advances

ISSN: 2158-3226 (Online)
Publisher: AIP Publishing LLC
Country of publisher: United States
LCC subjects: Science: Physics
Website: http://aipadvances.aip.org/

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