Nature Communications (Jan 2019)

Single-cell RNA-seq denoising using a deep count autoencoder

  • Gökcen Eraslan,
  • Lukas M. Simon,
  • Maria Mircea,
  • Nikola S. Mueller,
  • Fabian J. Theis

DOI
https://doi.org/10.1038/s41467-018-07931-2
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 14

Abstract

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Single-cell RNA sequencing is a powerful method to study gene expression, but noise in the data can obstruct analysis. Here the authors develop a denoising method based on a deep count autoencoder network that scales linearly with the number of cells, and therefore is compatible with large data sets.