Structure of DNMT3B homo-oligomer reveals vulnerability to impairment by ICF mutations

Linfeng Gao; Yiran Guo; Mahamaya Biswal; Jiuwei Lu; Jiekai Yin; Jian Fang; Xinyi Chen; Zengyu Shao; Mengjiang Huang; Yinsheng Wang; Gang Greg Wang; Jikui Song

doi:10.1038/s41467-022-31933-w

Nature Communications (Jul 2022)

Structure of DNMT3B homo-oligomer reveals vulnerability to impairment by ICF mutations

Linfeng Gao,
Yiran Guo,
Mahamaya Biswal,
Jiuwei Lu,
Jiekai Yin,
Jian Fang,
Xinyi Chen,
Zengyu Shao,
Mengjiang Huang,
Yinsheng Wang,
Gang Greg Wang,
Jikui Song

Affiliations

Linfeng Gao: Environmental Toxicology Graduate Program, University of California
Yiran Guo: Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill School of Medicine
Mahamaya Biswal: Department of Biochemistry, University of California
Jiuwei Lu: Department of Biochemistry, University of California
Jiekai Yin: Environmental Toxicology Graduate Program, University of California
Jian Fang: Department of Biochemistry, University of California
Xinyi Chen: Department of Biochemistry, University of California
Zengyu Shao: Department of Biochemistry, University of California
Mengjiang Huang: Department of Biochemistry, University of California
Yinsheng Wang: Environmental Toxicology Graduate Program, University of California
Gang Greg Wang: Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill School of Medicine
Jikui Song: Environmental Toxicology Graduate Program, University of California

DOI: https://doi.org/10.1038/s41467-022-31933-w
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 11

Abstract

Read online

In mammals, de novo DNA methyltransferase DNMT3B is essential for establishing DNA methylation patterns during embryonic development. Here the authors provide a structure-function characterization of homo-oligomeric DNMT3B, revealing the molecular basis for its vulnerability to ICF mutations.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal