Burning and Scaling Probably Associated with Dupilumab Therapy: A Case Report

Abstract

Nana Luo,1,2 Qiuyue Wang,1 Min Lei,1 Zhiyong Li,1 Tianhao Li,2 Pingsheng Hao2 1School of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, People’s Republic of China; 2Department of Dermatology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, People’s Republic of ChinaCorrespondence: Tianhao Li; Pingsheng Hao, Hospital of Chengdu University of Traditional Chinese Medicine, No. 39 Shi-er-qiao Road, Chengdu, Sichuan Province, People’s Republic of China, Tel [phone], Fax [phone], Email [email protected]; [email protected] Report: We present the case of a 51-year-old male who experienced temporary desquamation and recurrent burning sensation in primary skin lesions after the injection of dupilumab. The scaling lasted for 1 week and subsided, while the burning became aggravated with each injection of dupilumab, which gradually subsides after 8 weeks, and there was no recurrence since then.Conclusion: Dupilumab is an emerging and efficacious biologics medication for AD. The burning sensation and scaling we report may be the adverse events of dupilumab. Rare adverse reactions to biologics deserve the attention of physicians.Keywords: dupilumab, atopic dermatitis, burning, scaling, adverse event

Keywords

• dupilumab
• atopic dermatitis
• burning
• scaling
• adverse event