Nature Communications (Mar 2017)

T cell costimulation blockade blunts pressure overload-induced heart failure

  • Marinos Kallikourdis,
  • Elisa Martini,
  • Pierluigi Carullo,
  • Claudia Sardi,
  • Giuliana Roselli,
  • Carolina M. Greco,
  • Debora Vignali,
  • Federica Riva,
  • Anne Marie Ormbostad Berre,
  • Tomas O. Stølen,
  • Andrea Fumero,
  • Giuseppe Faggian,
  • Elisa Di Pasquale,
  • Leonardo Elia,
  • Cristiano Rumio,
  • Daniele Catalucci,
  • Roberto Papait,
  • Gianluigi Condorelli

Journal volume & issue
Vol. 8, no. 1
pp. 1 – 14


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Abatacept is an FDA-approved drug used for treatment of rheumatoid arthritis. Here the authors show that abatacept reduces cardiomyocyte death in a mouse model of heart failure by inhibiting activation and heart infiltration of T cells and macrophages, an effect mediated by IL-10, suggesting a potential therapy for heart failure.