Nature Communications (Nov 2018)
A hPSC-based platform to discover gene-environment interactions that impact human β-cell and dopamine neuron survival
- Ting Zhou,
- Tae Wan Kim,
- Chi Nok Chong,
- Lei Tan,
- Sadaf Amin,
- Zohreh Sadat Badieyan,
- Suranjit Mukherjee,
- Zaniar Ghazizadeh,
- Hui Zeng,
- Min Guo,
- Miguel Crespo,
- Tuo Zhang,
- Reyn Kenyon,
- Christopher L. Robinson,
- Effie Apostolou,
- Hui Wang,
- Jenny Zhaoying Xiang,
- Todd Evans,
- Lorenz Studer,
- Shuibing Chen
Affiliations
- Ting Zhou
- Department of Surgery, Weill Cornell Medical College
- Tae Wan Kim
- The Center for Stem Cell Biology, Sloan-Kettering Institute for Cancer Research
- Chi Nok Chong
- Department of Surgery, Weill Cornell Medical College
- Lei Tan
- Department of Surgery, Weill Cornell Medical College
- Sadaf Amin
- Department of Surgery, Weill Cornell Medical College
- Zohreh Sadat Badieyan
- Department of Surgery, Weill Cornell Medical College
- Suranjit Mukherjee
- Department of Surgery, Weill Cornell Medical College
- Zaniar Ghazizadeh
- Department of Surgery, Weill Cornell Medical College
- Hui Zeng
- Department of Surgery, Weill Cornell Medical College
- Min Guo
- Department of Surgery, Weill Cornell Medical College
- Miguel Crespo
- Department of Surgery, Weill Cornell Medical College
- Tuo Zhang
- Genomic Resource Core Facility, Weill Cornell Medical College
- Reyn Kenyon
- Department of Surgery, Weill Cornell Medical College
- Christopher L. Robinson
- Department of Surgery, Weill Cornell Medical College
- Effie Apostolou
- Department of Medicine, Weill Cornell Medical College
- Hui Wang
- School of Public health, Shanghai Jiao Tong University, School of Medicine
- Jenny Zhaoying Xiang
- Genomic Resource Core Facility, Weill Cornell Medical College
- Todd Evans
- Department of Surgery, Weill Cornell Medical College
- Lorenz Studer
- The Center for Stem Cell Biology, Sloan-Kettering Institute for Cancer Research
- Shuibing Chen
- Department of Surgery, Weill Cornell Medical College
- DOI
- https://doi.org/10.1038/s41467-018-07201-1
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 13
Abstract
Diseases such as diabetes and Parkinson's manifest based on interactions between genes and environment. Here, the authors find among a panel of cell types that propargite, a common pesticide, induces pancreatic β-cell and dopamine neuron death and that loss of the gene GSTT1 confers hypersensitivity.
