Nature Communications (Nov 2022)

Epigenetic regulation of white adipose tissue plasticity and energy metabolism by nucleosome binding HMGN proteins

  • Ravikanth Nanduri,
  • Takashi Furusawa,
  • Alexei Lobanov,
  • Bing He,
  • Carol Xie,
  • Kimia Dadkhah,
  • Michael C. Kelly,
  • Oksana Gavrilova,
  • Frank J. Gonzalez,
  • Michael Bustin

DOI
https://doi.org/10.1038/s41467-022-34964-5
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 15

Abstract

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White adipose tissue browning plays an important role in regulating whole-body energy homeostasis and metabolism. Here the authors show that the HMGN nucleosome binding proteins epigenetically promote white adipocyte differentiation and modulate the rate of white adipose tissue browning and energy metabolism in male mice.