New Approaches to the Prevention of Visceral Leishmaniasis: A Review of Recent Patents of Potential Candidates for a Chimeric Protein Vaccine
Diana Souza de Oliveira,
Maykelin Fuentes Zaldívar,
Ana Alice Maia Gonçalves,
Lucilene Aparecida Resende,
Reysla Maria da Silveira Mariano,
Diogo Fonseca Soares Pereira,
Ingrid dos Santos Soares Conrado,
Mariana Amália Figueiredo Costa,
Daniel Ferreira Lair,
Diego Fernandes Vilas-Boas,
Eiji Nakasone Nakasone,
Ingrid de Sousa Ameno,
Wanessa Moreira Goes,
Denise Silveira-Lemos,
Alexsandro Sobreira Galdino,
Ronaldo Alves Pinto Nagem,
Walderez Ornelas Dutra,
Rodolfo Cordeiro Giunchetti
Affiliations
Diana Souza de Oliveira
Laboratory of Biology of Cell Interactions, Department of Morphology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte 31270-901, MG, Brazil
Maykelin Fuentes Zaldívar
Laboratory of Biology of Cell Interactions, Department of Morphology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte 31270-901, MG, Brazil
Ana Alice Maia Gonçalves
Laboratory of Biotechnology of Microorganisms, Federal University of São João Del-Rei, Divinópolis 35501-296, MG, Brazil
Lucilene Aparecida Resende
Laboratory of Biology of Cell Interactions, Department of Morphology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte 31270-901, MG, Brazil
Reysla Maria da Silveira Mariano
Laboratory of Biology of Cell Interactions, Department of Morphology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte 31270-901, MG, Brazil
Diogo Fonseca Soares Pereira
Laboratory of Biology of Cell Interactions, Department of Morphology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte 31270-901, MG, Brazil
Ingrid dos Santos Soares Conrado
Laboratory of Biology of Cell Interactions, Department of Morphology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte 31270-901, MG, Brazil
Mariana Amália Figueiredo Costa
Structural Biology Laboratory, Department of Morphology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte 31270-901, MG, Brazil
Daniel Ferreira Lair
Laboratory of Biology of Cell Interactions, Department of Morphology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte 31270-901, MG, Brazil
Diego Fernandes Vilas-Boas
Laboratory of Biology of Cell Interactions, Department of Morphology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte 31270-901, MG, Brazil
Eiji Nakasone Nakasone
Laboratory of Biology of Cell Interactions, Department of Morphology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte 31270-901, MG, Brazil
Ingrid de Sousa Ameno
Laboratory of Biology of Cell Interactions, Department of Morphology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte 31270-901, MG, Brazil
Wanessa Moreira Goes
Laboratory of Biology of Cell Interactions, Department of Morphology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte 31270-901, MG, Brazil
Denise Silveira-Lemos
Laboratory of Biology of Cell Interactions, Department of Morphology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte 31270-901, MG, Brazil
Alexsandro Sobreira Galdino
Laboratory of Biotechnology of Microorganisms, Federal University of São João Del-Rei, Divinópolis 35501-296, MG, Brazil
Ronaldo Alves Pinto Nagem
Structural Biology Laboratory, Department of Morphology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte 31270-901, MG, Brazil
Walderez Ornelas Dutra
Laboratory of Biology of Cell Interactions, Department of Morphology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte 31270-901, MG, Brazil
Rodolfo Cordeiro Giunchetti
Laboratory of Biology of Cell Interactions, Department of Morphology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte 31270-901, MG, Brazil
The development of prophylactic vaccines is important in preventing and controlling diseases such as visceral leishmaniasis (VL), in addition to being an economic measure for public health. Despite the efforts to develop a vaccine against human VL caused by Leishmania infantum, none is available, and the focus has shifted to developing vaccines against canine visceral leishmaniasis (CVL). Currently, commercially available vaccines are targeted at CVL but are not effective. Different strategies have been applied in developing and improving vaccines, such as using chimeric proteins to expand vaccine coverage. The search for patents can be a way of tracking vaccines that have the potential to be marketed. In this context, the present work presents a summary of immunological aspects relevant to VL vaccine development with a focus on the composition of chimeric protein vaccines for CVL deposited in patent banks as an important approach for biotechnological development. The resulting data could facilitate the screening and selection of antigens to compose vaccine candidates with high performance against VL.
