Cutaneous ichthyosis secondary to isoniazid

Abstract

Introduction: Ichthyosis is a rare dermatological affection characterized by keratinization disorder. The occurrence of acquired ichthyosis in adults is an indicator of systemic disease. Ichthyosis can also reveal infectious diseases, or complicate medication. We report a case of ichthyosis secondary to isoniazid. Case: A man aged 75 years was treated for pleural tuberculosis. At the 3rd month of treatment, he develops cutaneous ichthyosis which regressed after discontinuation of antituberculous treatment. The reintroduction of isoniazid did reappear cutaneous ichthyosis. The dosage adjustment allows the improvement of lesions. Discussion: Isoniazid may be a cause of cutaneous ichthyosis. Tuberculosis can promote it.

Keywords

• Acquired ichthyosis
• Side effect/isoniazid
• Ichthyosis