Frontiers in Endocrinology (Jul 2020)
Impaired Fasting Glucose and Diabetes Are Related to Higher Risks of Complications and Mortality Among Patients With Coronavirus Disease 2019
- Jiaoyue Zhang,
- Jiaoyue Zhang,
- Wen Kong,
- Wen Kong,
- Pengfei Xia,
- Ying Xu,
- Li Li,
- Qin Li,
- Li Yang,
- Qi Wei,
- Hanyu Wang,
- Hanyu Wang,
- Huiqing Li,
- Huiqing Li,
- Juan Zheng,
- Juan Zheng,
- Hui Sun,
- Hui Sun,
- Wenfang Xia,
- Wenfang Xia,
- Geng Liu,
- Geng Liu,
- Xueyu Zhong,
- Xueyu Zhong,
- Kangli Qiu,
- Kangli Qiu,
- Yan Li,
- Han Wang,
- Han Wang,
- Yuxiu Wang,
- Yuxiu Wang,
- Xiaoli Song,
- Xiaoli Song,
- Hua Liu,
- Hua Liu,
- Si Xiong,
- Yumei Liu,
- Zhenhai Cui,
- Zhenhai Cui,
- Yu Hu,
- Yu Hu,
- Lulu Chen,
- Lulu Chen,
- An Pan,
- Tianshu Zeng,
- Tianshu Zeng
Affiliations
- Jiaoyue Zhang
- Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- Jiaoyue Zhang
- Hubei Provincial Clinical Research Center for Diabetes and Metabolic Disorders, Wuhan, China
- Wen Kong
- Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- Wen Kong
- Hubei Provincial Clinical Research Center for Diabetes and Metabolic Disorders, Wuhan, China
- Pengfei Xia
- Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- Ying Xu
- Department of Endocrinology, The Fifth Hospital of Wuhan, Wuhan, China
- Li Li
- Department of Endocrinology, Wuhan Wuchang Hospital, Wuchang Hospital Affiliated to Wuhan University of Science and Technology, Wuhan, China
- Qin Li
- Department of Endocrinology, General Hospital of the Yangtze River Shipping, Wuhan, China
- Li Yang
- Department of Endocrinology, Hankou Hospital of Wuhan City, Wuhan, China
- Qi Wei
- Department of Endocrinology, Red Cross Hospital of Wuhan City, Wuhan, China
- Hanyu Wang
- Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- Hanyu Wang
- Hubei Provincial Clinical Research Center for Diabetes and Metabolic Disorders, Wuhan, China
- Huiqing Li
- Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- Huiqing Li
- Hubei Provincial Clinical Research Center for Diabetes and Metabolic Disorders, Wuhan, China
- Juan Zheng
- Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- Juan Zheng
- Hubei Provincial Clinical Research Center for Diabetes and Metabolic Disorders, Wuhan, China
- Hui Sun
- Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- Hui Sun
- Hubei Provincial Clinical Research Center for Diabetes and Metabolic Disorders, Wuhan, China
- Wenfang Xia
- Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- Wenfang Xia
- Hubei Provincial Clinical Research Center for Diabetes and Metabolic Disorders, Wuhan, China
- Geng Liu
- Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- Geng Liu
- Hubei Provincial Clinical Research Center for Diabetes and Metabolic Disorders, Wuhan, China
- Xueyu Zhong
- Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- Xueyu Zhong
- Hubei Provincial Clinical Research Center for Diabetes and Metabolic Disorders, Wuhan, China
- Kangli Qiu
- Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- Kangli Qiu
- Hubei Provincial Clinical Research Center for Diabetes and Metabolic Disorders, Wuhan, China
- Yan Li
- Department of Endocrinology, Wuhan Wuchang Hospital, Wuchang Hospital Affiliated to Wuhan University of Science and Technology, Wuhan, China
- Han Wang
- Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- Han Wang
- Hubei Provincial Clinical Research Center for Diabetes and Metabolic Disorders, Wuhan, China
- Yuxiu Wang
- Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- Yuxiu Wang
- Hubei Provincial Clinical Research Center for Diabetes and Metabolic Disorders, Wuhan, China
- Xiaoli Song
- Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- Xiaoli Song
- Hubei Provincial Clinical Research Center for Diabetes and Metabolic Disorders, Wuhan, China
- Hua Liu
- Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- Hua Liu
- Hubei Provincial Clinical Research Center for Diabetes and Metabolic Disorders, Wuhan, China
- Si Xiong
- Department of Endocrinology, The Fifth Hospital of Wuhan, Wuhan, China
- Yumei Liu
- Department of Endocrinology, Hankou Hospital of Wuhan City, Wuhan, China
- Zhenhai Cui
- Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- Zhenhai Cui
- Hubei Provincial Clinical Research Center for Diabetes and Metabolic Disorders, Wuhan, China
- Yu Hu
- Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- Yu Hu
- 0Hubei Clinical and Research Centre of Thrombosis and Haemostasis, Wuhan, China
- Lulu Chen
- Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- Lulu Chen
- Hubei Provincial Clinical Research Center for Diabetes and Metabolic Disorders, Wuhan, China
- An Pan
- Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- Tianshu Zeng
- Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- Tianshu Zeng
- Hubei Provincial Clinical Research Center for Diabetes and Metabolic Disorders, Wuhan, China
- DOI
- https://doi.org/10.3389/fendo.2020.00525
- Journal volume & issue
-
Vol. 11
Abstract
Background: Diabetes correlates with poor prognosis in patients with COVID-19, but very few studies have evaluated whether impaired fasting glucose (IFG) is also a risk factor for the poor outcomes of patients with COVID-19. Here we aimed to examine the associations between IFG and diabetes at admission with risks of complications and mortality among patients with COVID-19.Methods: In this multicenter retrospective cohort study, we enrolled 312 hospitalized patients with COVID-19 from 5 hospitals in Wuhan from Jan 1 to Mar 17, 2020. Clinical information, laboratory findings, complications, treatment regimens, and mortality status were collected. The associations between hyperglycemia and diabetes status at admission with primary composite end-point events (including mechanical ventilation, admission to intensive care unit, or death) were analyzed by Cox proportional hazards regression models.Results: The median age of the patients was 57 years (interquartile range 38–66), and 172 (55%) were women. At the time of hospital admission, 84 (27%) had diabetes (and 36 were new-diagnosed), 62 (20%) had IFG, and 166 (53%) had normal fasting glucose (NFG) levels. Compared to patients with NFG, patients with IFG and diabetes developed more primary composite end-point events (9 [5%], 11 [18%], 26 [31%]), including receiving mechanical ventilation (5 [3%], 6 [10%], 21 [25%]), and death (4 [2%], 9 [15%], 20 [24%]). Multivariable Cox regression analyses showed diabetes was associated increased risks of primary composite end-point events (hazard ratio 3.53; 95% confidence interval 1.48–8.40) and mortality (6.25; 1.91–20.45), and IFG was associated with an increased risk of mortality (4.11; 1.15–14.74), after adjusting for age, sex, hospitals and comorbidities.Conclusion: IFG and diabetes at admission were associated with higher risks of adverse outcomes among patients with COVID-19.
Keywords