ABOUT NEW COMPLEXES TIN (IV) WITH 5– BROM SALICYLOYLHYDRAZONES OF SUBSTITUTED OF BENZALDEHYDE

Abstract

The complexes [SnCl4(5-Br-2-OH-HB-4R-b)] (R = OCH3 (I), Br(II) and [SnCl4(5-Br-2-OHB-4R-b∙H)] (R = N(CH3)2 (III)) were obtained by interaction of SnCl4 with 5– brom-salicyloylhydrazones 4–R– benzaldehydes (5-Br-2-OH-HB-4R-b) in acetonitrile. In the complexes is realized bidentate O(C=O/C-O), N(CH=N) – coordination of ketone (I, II) or the enol, the protonated tertiary nitrogen atom of the aldehyde fragment form of the ligand (III). It was studied the anti-inflammatory activity of (I-III) in model of aseptic carrageenan induced swelling.

Keywords

• протизапальна активність
• станум (IV)
• SnCl4
• гідразони
• координаційні сполуки