Communications Biology (Feb 2021)
βA1-crystallin regulates glucose metabolism and mitochondrial function in mouse retinal astrocytes by modulating PTP1B activity
- Sayan Ghosh,
- Haitao Liu,
- Meysam Yazdankhah,
- Nadezda Stepicheva,
- Peng Shang,
- Tanuja Vaidya,
- Stacey Hose,
- Urvi Gupta,
- Michael Joseph Calderon,
- Ming-Wen Hu,
- Archana Padmanabhan Nair,
- Joseph Weiss,
- Christopher S. Fitting,
- Imran A. Bhutto,
- Santosh Gopi Krishna Gadde,
- Naveen Kumar Naik,
- Chaitra Jaydev,
- Gerard A. Lutty,
- James T. Handa,
- Ashwath Jayagopal,
- Jiang Qian,
- José-Alain Sahel,
- Dhivyaa Rajasundaram,
- Yuri Sergeev,
- J. Samuel Zigler,
- Swaminathan Sethu,
- Simon Watkins,
- Arkasubhra Ghosh,
- Debasish Sinha
Affiliations
- Sayan Ghosh
- Department of Ophthalmology, University of Pittsburgh School of Medicine
- Haitao Liu
- Department of Ophthalmology, University of Pittsburgh School of Medicine
- Meysam Yazdankhah
- Department of Ophthalmology, University of Pittsburgh School of Medicine
- Nadezda Stepicheva
- Department of Ophthalmology, University of Pittsburgh School of Medicine
- Peng Shang
- Department of Ophthalmology, University of Pittsburgh School of Medicine
- Tanuja Vaidya
- GROW Research Laboratory, Narayana Nethralaya Foundation
- Stacey Hose
- Department of Ophthalmology, University of Pittsburgh School of Medicine
- Urvi Gupta
- Department of Ophthalmology, University of Pittsburgh School of Medicine
- Michael Joseph Calderon
- Department of Cell Biology and Center for Biologic Imaging, University of Pittsburgh School of Medicine
- Ming-Wen Hu
- Wilmer Eye Institute, The Johns Hopkins University School of Medicine
- Archana Padmanabhan Nair
- GROW Research Laboratory, Narayana Nethralaya Foundation
- Joseph Weiss
- Department of Ophthalmology, University of Pittsburgh School of Medicine
- Christopher S. Fitting
- Department of Ophthalmology, University of Pittsburgh School of Medicine
- Imran A. Bhutto
- Wilmer Eye Institute, The Johns Hopkins University School of Medicine
- Santosh Gopi Krishna Gadde
- GROW Research Laboratory, Narayana Nethralaya Foundation
- Naveen Kumar Naik
- GROW Research Laboratory, Narayana Nethralaya Foundation
- Chaitra Jaydev
- GROW Research Laboratory, Narayana Nethralaya Foundation
- Gerard A. Lutty
- Wilmer Eye Institute, The Johns Hopkins University School of Medicine
- James T. Handa
- Wilmer Eye Institute, The Johns Hopkins University School of Medicine
- Ashwath Jayagopal
- Kodiak Sciences
- Jiang Qian
- Wilmer Eye Institute, The Johns Hopkins University School of Medicine
- José-Alain Sahel
- Department of Ophthalmology, University of Pittsburgh School of Medicine
- Dhivyaa Rajasundaram
- Department of Pediatrics, Children’s Hospital of Pittsburgh, University of Pittsburgh School of Medicine
- Yuri Sergeev
- National Eye Institute, National Institutes of Health
- J. Samuel Zigler
- Wilmer Eye Institute, The Johns Hopkins University School of Medicine
- Swaminathan Sethu
- GROW Research Laboratory, Narayana Nethralaya Foundation
- Simon Watkins
- Department of Cell Biology and Center for Biologic Imaging, University of Pittsburgh School of Medicine
- Arkasubhra Ghosh
- GROW Research Laboratory, Narayana Nethralaya Foundation
- Debasish Sinha
- Department of Ophthalmology, University of Pittsburgh School of Medicine
- DOI
- https://doi.org/10.1038/s42003-021-01763-5
- Journal volume & issue
-
Vol. 4,
no. 1
pp. 1 – 19
Abstract
Ghosh et al. show that a lens protein βA1-crystallin inhibits PTP1B activity, regulating the metabolism of retinal astrocytes. They find that knockdown of βA1-crystallin exacerbates the streptozotocin-induced diabetic retinopathy-like phenotype in mice, suggesting the possibility that the interaction between βA1-PTP1B may be targeted for diabetic retinopathy.
