Usefulness of plasma glucose to potassium ratio in predicting the short-term mortality of patients with aneurysmal subarachnoid hemorrhage

Abstract

Rationale and objectives: To investigate the relationship between the glucose/potassium ratio (GPR) at admission and 30-day mortality in patients diagnosed with aneurysmal subarachnoid hemorrhage (SAH) in the emergency department (ED). Materials and methods: Patients with a modified Rankin Scale (mRS) score of ≤2 before SAH and patients aged 18 years or older were included in the study. The patients were divided into two groups based on their functional outcomes (poor-good) and 30-day mortality rates (survivor and non-survivor) and their clinical and laboratory values were compared. Results: The study included 134 patients with a mean age of 65.9 ± 16.7 years, of whom 68 (50.7 %) were female. The mean glucose and GPR levels in the poor functional outcome group were significantly higher than those in the good functional outcome group (p = 0.003, p = 0.03, respectively). The mean glucose and GPR levels in the non-survivor group were significantly higher than those in the survivor group (p = 0.004, p = 0.023, respectively). Multivariate logistic regression analysis identified GPR as an independent predictor of 30-day mortality (p = 0.043, OR: 4.041, 95 % CI: 1.45–26.147), alongside the Rankin Scale score (p = 0.002, OR: 12.714, 95 % CI: 2.578–62.706). Other variables, including age, Hunt-Hess score, and Glasgow Coma Scale, were not statistically significant. Conclusion: The findings indicate that the GPR is a significant independent predictor of short-term mortality in patients with aneurysmal subarachnoid hemorrhage. The translation of these findings into clinical practice may help achieve better outcomes in the management of SAH patients.

Keywords

• Aneurysmal subarachnoid hemorrhage
• Glucose
• Potassium
• Mortality