Cytotoxicity Studies of Eugenol Amino Alcohols Derivatives

Abstract

Eugenol is a phenylpropanoid displaying a wide range of biological activities. In this study, the cytotoxic activity of various β-amino alcohols derivatives from eugenol was evaluated in AGS (gastric cancer) and A549 (lung cancer) cell lines. The results show that some structural modifications resulted in enhanced cytotoxic activity towards cancer cells. In addition, the activation of caspase-3 and hence apoptosis induced by these molecules, was also explored. Considering the obtained results, some structure/activity relationships can be drawn, which may guide future structural improvements for anticancer agents.

Keywords

• eugenol
• β-amino alcohols
• essential oils
• cytotoxicity
• caspase-3
• anticancer