Nature Communications (Jul 2018)
Direct reprogramming of fibroblasts into neural stem cells by single non-neural progenitor transcription factor Ptf1a
- Dongchang Xiao,
- Xiaoning Liu,
- Min Zhang,
- Min Zou,
- Qinqin Deng,
- Dayu Sun,
- Xuting Bian,
- Yulong Cai,
- Yanan Guo,
- Shuting Liu,
- Shengguo Li,
- Evelyn Shiang,
- Hongyu Zhong,
- Lin Cheng,
- Haiwei Xu,
- Kangxin Jin,
- Mengqing Xiang
Affiliations
- Dongchang Xiao
- State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University
- Xiaoning Liu
- State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University
- Min Zhang
- State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University
- Min Zou
- Center for Advanced Biotechnology and Medicine and Department of Pediatrics, Rutgers University-Robert Wood Johnson Medical School
- Qinqin Deng
- State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University
- Dayu Sun
- Southwest Hospital/Southwest Eye Hospital, Third Military Medical University
- Xuting Bian
- Department of Developmental Neuropsychology, School of Psychology, Third Military Medical University
- Yulong Cai
- Department of Developmental Neuropsychology, School of Psychology, Third Military Medical University
- Yanan Guo
- State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University
- Shuting Liu
- State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University
- Shengguo Li
- Center for Advanced Biotechnology and Medicine and Department of Pediatrics, Rutgers University-Robert Wood Johnson Medical School
- Evelyn Shiang
- Center for Advanced Biotechnology and Medicine and Department of Pediatrics, Rutgers University-Robert Wood Johnson Medical School
- Hongyu Zhong
- Department of Developmental Neuropsychology, School of Psychology, Third Military Medical University
- Lin Cheng
- State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University
- Haiwei Xu
- Southwest Hospital/Southwest Eye Hospital, Third Military Medical University
- Kangxin Jin
- State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University
- Mengqing Xiang
- State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University
- DOI
- https://doi.org/10.1038/s41467-018-05209-1
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 19
Abstract
Fibroblasts can be reprogrammed into induced neural stem cells (iNSCs) using transcription factors expressed in neural progenitors. Here the authors show that Ptf1a, which is normally expressed in postmitotic neurons, can reprogram fibroblasts to iNSCs through Notch independent interaction with Rbpj.
