Nature Communications (Mar 2018)

CoA synthase regulates mitotic fidelity via CBP-mediated acetylation

  • Chao-Chieh Lin,
  • Mayumi Kitagawa,
  • Xiaohu Tang,
  • Ming-Hsin Hou,
  • Jianli Wu,
  • Dan Chen Qu,
  • Vinayaka Srinivas,
  • Xiaojing Liu,
  • J. Will Thompson,
  • Bernard Mathey-Prevot,
  • Tso-Pang Yao,
  • Sang Hyun Lee,
  • Jen-Tsan Chi

DOI
https://doi.org/10.1038/s41467-018-03422-6
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 14

Abstract

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The temporal activation of kinases and timely ubiquitin-mediated degradation is central to faithful mitosis. Here the authors show that acetylation controlled by Coenzyme A synthase (COASY) and acetyltransferase CBP constitutes a mechanism that ensures faithful mitosis.