The Perlman syndrome DIS3L2 exoribonuclease safeguards endoplasmic reticulum-targeted mRNA translation and calcium ion homeostasis

Mehdi Pirouz; Chih-Hao Wang; Qi Liu; Aref G. Ebrahimi; Farnaz Shamsi; Yu-Hua Tseng; Richard I. Gregory

doi:10.1038/s41467-020-16418-y

Nature Communications (May 2020)

The Perlman syndrome DIS3L2 exoribonuclease safeguards endoplasmic reticulum-targeted mRNA translation and calcium ion homeostasis

Mehdi Pirouz,
Chih-Hao Wang,
Qi Liu,
Aref G. Ebrahimi,
Farnaz Shamsi,
Yu-Hua Tseng,
Richard I. Gregory

Affiliations

Mehdi Pirouz: Stem Cell Program, Division of Hematology/Oncology, Boston Children’s Hospital
Chih-Hao Wang: Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School
Qi Liu: Stem Cell Program, Division of Hematology/Oncology, Boston Children’s Hospital
Aref G. Ebrahimi: Section on Islet Cell and Regenerative Biology, Joslin Diabetes Center, Harvard Medical School
Farnaz Shamsi: Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School
Yu-Hua Tseng: Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School
Richard I. Gregory: Stem Cell Program, Division of Hematology/Oncology, Boston Children’s Hospital

DOI: https://doi.org/10.1038/s41467-020-16418-y
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 13

Abstract

Read online

The DIS3L2 exonuclease degrades aberrant 7SL RNAs tagged by an oligouridine 3′-tail. Here the authors analyze DIS3L2 knockout mouse embryonic stem cells and suggest that DIS3L2-mediated quality control of 7SL RNA is important for ER-mediated translation and calcium ion homeostasis.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal